Results 211 to 220 of about 8,037,414 (303)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Individual and Contextual Factors Associated with the Need for and Use of Dental Prostheses in Brazil: A Multilevel Analysis of SB Brasil 2023 Data. [PDF]

Rev Bras Epidemiol
Menezes LXB, Martins LMA, Raymundo MLB, Feitosa RR, Catão NES, Lira Neto AC, Silva ROD, Bomfim RA, Cavalcanti YW.   +8 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Educational Trajectories and Academic Achievement from Primary to Secondary Education: A Systematic Review of Individual, Family, School, and Contextual Factors. [PDF]

Behav Sci (Basel)
Salvo-Garrido S, Polanco-Levicán K, Cisternas-Salcedo P, Moraga-Pumarino A.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The dual effects of individual and contextual factors on adolescent problematic internet use: Machine learning approaches and SHAP explanations. [PDF]

J Behav Addict
Huang K, Yang Y, Wang L, Li J, Qu D, Chen R, Chi X.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Multilevel Associations Between Outlet Characteristics, Contextual Factors and Firearm Violence at On-Premise Alcohol Outlets in the United States. [PDF]

Drug Alcohol Rev
Bushover B, Roberts LE, Mehranbod CA, Morrison CN.   +3 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Experiences and Contextual Factors Impacting AAC Use at Home: A Qualitative Interview Study. [PDF]

Topics Early Child Spec Educ
Quinn ED, Kurin K, Cook A, Therrien M, Romano M.   +4 more
europepmc   +1 more source