Results 261 to 270 of about 14,254,520 (384)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Exploring the Contextual Factors That Influence Polio Supplementary Immunisation Activities in the WHO African Region: A Rapid Review. [PDF]

Vaccines (Basel)
Adamu AA, Ndwandwe D, Ndoutabe M, Adamu US, Jalo RI, Abubakar K, Ticha JM, Ainan SA, Shibeshi M, Nomhwange T, Ahmed JA, Wiysonge CS.   +11 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

<i>"I'm Not Right to Drive, but I Drove out the Gate":</i> Personal and Contextual Factors Affecting Truck Driver Fatigue Compliance. [PDF]

Int J Environ Res Public Health
Casey GJ, Miles-Johnson T, Stevens GJ.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Assessing stakeholder perceptions and contextual factors in implementing post-discharge malaria chemoprevention in children with severe anaemia in Malawi. [PDF]

BMC Health Serv Res
Ndambo MK, Hoyt J, Nyirongo E, Phiri KS, Hill J, Manda-Taylor L.   +5 more
europepmc   +1 more source

Trajectories in county-level Low Birthweight Rates and Associated Contextual Factors in the United States, 2016-2021 [PDF]

Pallavi Dwivedi, Thu T. Nguyen, Xin He, Quynh C. Nguyen   +3 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Implementing nutrition policy, system and environmental change strategies in a rural food pantry to improve nutrition security: contextual factors and outcomes. [PDF]

Public Health Nutr
Hermstad AK, Bigger LM, Ebey-Tessendorf K, Simmons GC, Kegler MC.   +4 more
europepmc   +1 more source