Results 51 to 60 of about 253,119 (310)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Multi-Object Classification and Unsupervised Scene Understanding Using Deep Learning Features and Latent Tree Probabilistic Models [PDF]

, 2015
Deep learning has shown state-of-art classification performance on datasets such as ImageNet, which contain a single object in each image. However, multi-object classification is far more challenging.
Anandkumar, Anima, Nimmagadda, Tejaswi
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Visual and geographical data fusion to classify landmarks in geo-tagged images [PDF]

, 2012
High level semantic image recognition and classification is a challenging task and currently is a very active research domain. Computers struggle with the high level task of identifying objects and scenes within digital images accurately in unconstrained
Hughes, Mark, Jones, Gareth J.F., O'Connor, Noel E.   +2 more
core  

'Part'ly first among equals: Semantic part-based benchmarking for state-of-the-art object recognition systems

, 2016
An examination of object recognition challenge leaderboards (ILSVRC, PASCAL-VOC) reveals that the top-performing classifiers typically exhibit small differences amongst themselves in terms of error rate/mAP.
A Borji, A Khosla, A Torralba, CW Tyler, D Hoiem, GA Miller, L Xu, M Everingham, MD Zeiler, PF Felzenszwalb, SE Palmer, T Tommasi, T-Y Lin   +12 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Sleep-like slow oscillations improve visual classification through synaptic homeostasis and memory association in a thalamo-cortical model

, 2019
The occurrence of sleep passed through the evolutionary sieve and is widespread in animal species. Sleep is known to be beneficial to cognitive and mnemonic tasks, while chronic sleep deprivation is detrimental.
Capone, Cristiano, Golosio, Bruno, Paolucci, Pier Stanislao, Pastorelli, Elena   +3 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Context-based Object Viewpoint Estimation: A 2D Relational Approach

, 2017
The task of object viewpoint estimation has been a challenge since the early days of computer vision. To estimate the viewpoint (or pose) of an object, people have mostly looked at object intrinsic features, such as shape or appearance.
De Raedt, Luc, Oramas, Jose, Tuytelaars, Tinne   +2 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source