Results 41 to 50 of about 45,354 (260)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Implementation Science in Elementary Literacy: Fidelity, Adaptations, and Instructional Challenges
Education SciencesFidelity of implementation, how closely instructors follow intervention protocols, is critical for translating evidence-based educational programs into meaningful student outcomes.
Zoi A. Traga Philippakos +3 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Level-2 ecological integrity: Assessing ecosystems in a changing world
Perspectives in Ecology and Conservation, 2020 Ecological integrity is a term often used to describe the state of ecosystems subjected to anthropogenic pressures. It is usually defined closely to the literal definition of integrity: being whole or unimpaired. Considering the deep changes our world is
Charles A. Martin, Raphaël Proulx
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Balancing Minds and Data: The Privacy Dilemma of LLMs and Anthropomorphism in LLMs
Journal of Social ComputingThis essay examines the intricate relationship between large language models (LLMs) and privacy, investigating the ethical and practical issues stemming from cutting-edge artificial intelligence (AI) technologies.
Raffael Meier
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Transforming Family Privacy: Floridi and Nissenbaum on Digital Ethics
Şırnak Üniversitesi İlahiyat Fakültesi DergisiThis study uniquely focuses on the transformation of privacy in the digital age from an ethical perspective within the context of family structure. With the widespread use of digital technologies, privacy has evolved from a fixed and protected space to a
Nazan Yeşilkaya
doaj +1 more source
DigitCult@Scientific Journal on Digital Cultures, 2018 Nowadays, Social Media Platforms, (SMP) are increasingly central in mediating subjects’ interaction and communication. The flow of information that occurs in these platforms is governed by legal and technological norms.
Pasquale Pellegrino
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source