Results 51 to 60 of about 149,870 (301)

Architectural interpretations of spatial form based on cellular automata with application in balneal contexts [PDF]

open access: yesArhitektura i Urbanizam, 2009
The concept of cellular automata (CA) has been challenging various disciplines for many decades. In this study the concept has been examined in the process of spatial form generation.
Petruševski Ljiljana   +2 more
doaj  

Strategic Design through Brand Contextualization [PDF]

open access: yes, 2013
Providing meaningful customer experience is at the core of any successful business activity. Brands can function as vehicles to bundle the ingredients of experience together and give them structure by which consumers are able to understand and interpret ...
Karjalainen, Toni-Matti   +2 more
core  

Ambivalent pasts: colonial history and the theatricalities of ethnographic display [PDF]

open access: yes, 2017
In the twenty-first century, museums holding ethnographic collections have come under scrutiny for their implication in colonial history, and many have started to address this problematic legacy, often in conscious attempts to move beyond the colonial as
Bachmann, Michael
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Constraint contextual rewriting

open access: yesJournal of Symbolic Computation, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
ARMANDO, ALESSANDRO, RANISE S.
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Contexts for studying a medieval city, or On the benefits of “fruitless” discussions in the history of historical science [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: История. Международные отношения
In the article, the author continues reflections on the fundamental importance and heuristic potential of the consistent study of materials of scientific discussions for historical-historiographic research.
Repina, Lorina P.
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz   +3 more
wiley   +1 more source

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