Results 211 to 220 of about 5,833,303 (342)

PKRxiv: A Best Practice Model for Advancing Pharmacoequity Through Open Pharmacokinetic Data Sharing

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development is increasingly integrated across the drug development continuum, enabling more efficient, cost‐effective, and targeted trials while reducing reliance on animal studies. Achieving pharmacoequity requires not only equitable access to medicines but also to the data and knowledge that inform drug development and regulatory ...
Shakir Atoyebi, Prajith Venkatasubramanian, Abdulafeez Akinloye, Oluwasegun Eniayewu, Brookie M. Best, Laura Else, Adeniyi Olagunju   +6 more
wiley   +1 more source

Eccentricity rhythms in the Oligocene-Miocene carbon cycle regulated by weathering and carbonate burial. [PDF]

Sci Adv
Liu F, Huang E, Du J, Ma W, Liu Z, Lourens LJ, Tian J.   +6 more
europepmc   +1 more source

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

The mantle source of REE-rich alkaline silicate magmas can be enriched by continent-derived sediment subduction. [PDF]

Nat Commun
Qiu KF, Long ZY, Romer RL, Halama R, Williams-Jones AE, Yu HC, Li SS, Wu MQ, Deng J.   +8 more
europepmc   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Discovery of a heavy silicon isotope mantle reservoir. [PDF]

Natl Sci Rev
Liu MR, Wang J, Cui ZX, Wei GJ, Yang Q, Xu YG, Kerr AC, Wyman D, Bai JH, Zhu GH, Ma L, Hao LL, Zhou JS, Fan JJ, Huang TY, Zhang MY, Wang Q.   +16 more
europepmc   +1 more source

Industrial Sustainability Policies: Systematic Literature Review and Research Directions

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Public policies for industrial sustainability have proliferated in recent years, leading to a significant increase in research on the topic. Nevertheless, these studies remain fragmented, and a holistic, up‐to‐date map of research integrating current knowledge from the definition of the agenda setting and policy design to policy evaluation ...
Nunzia Zecchillo, Margherita Molinaro, Guido Orzes   +2 more
wiley   +1 more source

Intraplate deformation of Gondwana terranes and implications for the Wilson Cycle. [PDF]

Sci Rep
Fonseca A, De Grave J.
europepmc   +1 more source

ESG Performance Evolution in Retail: A Systematic Review and Meta‐Analysis

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Environmental, social, and governance (ESG) practices have transformed from peripheral corporate social responsibility initiatives into core strategic imperatives in retail. Despite growing interest, the literature remains fragmented across disciplines and geographic contexts, with no comprehensive sector‐specific analysis examining the ...
Jiyeon Kim, Wooyoung Yang
wiley   +1 more source

Update of the Köppen-Geiger climate classification for EFSA PLH risk assessment. [PDF]

EFSA J
European Food Safety Authority (EFSA), Rossi E, Maiorano A, Gobbi A.   +3 more
europepmc   +1 more source