Results 91 to 100 of about 129,344 (267)
A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules
Advanced Science, EarlyView.Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang +6 more
wiley +1 more source
Advanced Science, EarlyView.This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang +15 more
wiley +1 more source
Microbial Community Succession Sustains Fish Diversity in the Upper Yangtze River Reserve
Advanced Science, EarlyView.Critical for river ecosystem sustainability, fish diversity relates to multitrophic microbes. This upper Yangtze FNNR study used eDNA to examine microbial succession‐fish links, finding key drivers, distinct assembly processes, and that microbial cross‐trophic interactions benefit fish, offering conservation insights.
Jiaxin Huang +12 more
wiley +1 more source
Overall and Pairwise Segregation Tests Based on Nearest Neighbor Contingency Tables [PDF]
, 2008 Elvan Ceyhan
openalex +1 more source
The Role of Action–Effect Contingency on Sensory Attenuation in the Absence of Movement [PDF]
, 2022 Nathan Han +3 more
openalex +1 more source
Advanced Science, EarlyView.In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han +26 more
wiley +1 more source
Contingency and Necessity of Election, a study on “election” in Pannenberg's thought
, 2006 Masataka Hamazaki
openalex +2 more sources
Depth‐Dependence Changes in Soil Stoichiometry in China's Croplands Over the Past Four Decades
Advanced Science, EarlyView.This study reveals depth‐dependent changes in soil C:N:P ratios across Chinese croplands over four decades. Changes in stoichiometry vary markedly between topsoil and subsoil, with initial soil C:N:P ratios playing a key role in determining their trajectories.
Xiaodong Sun +8 more
wiley +1 more source
National contingency plan for response to unusual marine mammal mortality events
, 1996 Dean M. Wilkinson, U.S. Fish
openalex +2 more sources
Advanced Science, EarlyView.The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu +25 more
wiley +1 more source