Results 91 to 100 of about 6,043,564 (322)

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

Role of remote transformational leadership on service performance: evidence in Indonesia

Engineering Management in Production and Services, 2022
This study examined and analysed the role of remote transformational leadership in business strategy consensus by considering the contingency of competitive intensity and organisational learning culture. The population of this study are owners or service
Muafi Muafi, Johan Ahmad
doaj   +1 more source

In Situ Characterisation of Hydrogels via Dynamic Interface Printing

Advanced Science, EarlyView.
ABSTRACT Hydrogels have become pivotal materials for tissue engineering, robotics, biomedical devices, and sensing applications due to their diverse material compositions and tunable mechanical properties. While significant effort has focused on developing novel manufacturing approaches such as extrusion bioprinting and light‐based fabrication methods,
Callum Vidler, Michael Halwes, David J. Collins   +2 more
wiley   +1 more source

Context and time in causal learning: contingency and mood dependent effects. [PDF]

PLoS ONE, 2013
Defining cues for instrumental causality are the temporal, spatial and contingency relationships between actions and their effects. In this study, we carried out a series of causal learning experiments that systematically manipulated time and context in ...
Rachel M Msetfi, Caroline Wade, Robin A Murphy   +2 more
doaj   +1 more source

Infinite factorization of multiple non-parametric views [PDF]

, 2010
Combined analysis of multiple data sources has increasing application interest, in particular for distinguishing shared and source-specific aspects. We extend this rationale of classical canonical correlation analysis into a flexible, generative and non ...
A. Gelman, A. Klami, A. Klami, A. Rodriguez, A. Vinokourov, Arto Klami, C. Archambeau, C. Rasmussen, D. Blackwell, D. Blei, D. Cohn, D. Lee, D. M. Blei, D. M. Roy, G. Englebienne, I. Rivals, I. S. Dhillon, Janne Sinkkonen, K. Barnard, M. Welling, Mark Girolami, N. Friedman, N. L. Johnson, R. M. Neal, S. Becker, S. Rogers, Samuel Kaski, Simon Rogers, T. Hofmann, Y. W. Teh   +29 more
core   +2 more sources

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

ISPC effect is not observed when the word comes too late: A time course analysis

Frontiers in Psychology, 2014
The item-specific proportion congruency (ISPC) effect is demonstrated by a smaller Stroop effect observed for mostly incongruent items compared to mostly congruent items.
Nart Bedin Atalay, Mine eMisirlisoy
doaj   +1 more source

Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency

eLife, 2020
The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections.
Richard B. Crouse, Kristen Kim, Hannah M. Batchelor, Eric M Girardi, R. Kamaletdinova, Justin Chan, Prithviraj Rajebhosale, Steven T. Pittenger, L. Role, D. Talmage, Miao Jing, Yulong Li, Xiao-Bing Gao, Y. Mineur, M. Picciotto   +14 more
semanticscholar   +1 more source

Pengaruh Penerapan Moving Class terhadap Efektivitas Pembelajaran pada Mata Pelajaran Pendidikan Kewarganegaraan [PDF]

, 2013
The purpose of this study to explain include of moving class aplications towards learning effectiveness on ten class citizenship education at SMK N 5 Bandar Lampung lesson year 2012/2013.
negari, C. A. (citra), Nurmalisa, Y. (Yunisca), Pitoewas, B. (Berchah)   +2 more
core   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source