Results 31 to 40 of about 257,346 (272)

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

Profile Statistics for Sparse Contingency Tables under Poisson Sampling

Austrian Journal of Statistics, 2016
Simple conditions for the inconsistency of classical likelihood ratio (LR) test in case of very sparse categorical data are given. The LR type test based on profile statistics is proposed as an alternative.
Marijus Radavičius, Pavel Samusenko
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Challenging computations of Hilbert bases of cones associated with algebraic statistics [PDF]

, 2010
In this paper we present two independent computational proofs that the monoid derived from $5\times 5\times 3$ contingency tables is normal, completing the classification by Hibi and Ohsugi. We show that Vlach's vector disproving normality for the monoid
Bruns, Winfried, Hemmecke, Raymond, Ichim, Bogdan, Koeppe, Matthias, Soeger, Christof   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

SVD, discrepancy, and regular structure of contingency tables

, 2013
We will use the factors obtained by correspondence analysis to find biclustering of a contingency table such that the row-column cluster pairs are regular, i.e., they have small discrepancy.
Bolla, Marianna
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Partial Information Releases for Confidential Contingency Table Entries: Present and Future Research Efforts

The Journal of Privacy and Confidentiality, 2010
Tabular data have been a staple product for disseminating information derived from the confidential microdata that fuel social science research and inform policy decisions. This paper outlines recent results on disclosure risk assessment associated with
Aleksandra B. Slavkovic
doaj   +1 more source

Observed Range Maximum Likelihood Estimation [PDF]

, 2011
The idea of maximizing the likelihood of the observed range for a set of jointly realized counts has been employed in a variety of contexts. The applicability of the MLE introduced in [1] has been extended to the general case of a multivariate sample ...
Markov, Plamen
core  

Binary Models for Marginal Independence

, 2007
Log-linear models are a classical tool for the analysis of contingency tables. In particular, the subclass of graphical log-linear models provides a general framework for modelling conditional independences.
Anderson T. W, Anderson T. W., Bergsma W, Bergsma W, Bertsekas D. P, Besag J., Cox D. R., Cox D. R., Dawid A. P., Drton M., Edwards D. M, Ekholm A., Ekholm A., Erdos P., Glonek G. F. V., Hinton G. E., Hojsgaard S, Kauermann G., Kauermann G., Kendler K. S., Kennes R., Knuth D. E, Lauritzen S. L., Levi M., Mao Y., Marchetti G. M., McCullagh P., McCullagh P., Moore A., Pearl J., Pearl J., Putnam R., R Development Core Team, Sztompka P., Wright S.   +34 more
core   +2 more sources