Results 151 to 160 of about 22,989 (261)

Direct Comparison Between Loss‐to‐Follow‐Up and Statistical Fragility Is Methodologically Inappropriate, and Fragility Reflects the P Value, Not Trial Robustness: A Simulation Analysis of 300,000 Randomized Controlled Trials

open access: yesArthroscopy, EarlyView.
Purpose To assess the relation between the fragility index (FI) and reverse fragility index (RFI) with the minimum number of patients needed to reverse statistical significance (e.g. henceforth termed the lost to follow‐up index (LTFI) and reverse LTFI (R‐LTFI), respectively) and apply machine learning to identify which trial parameters are most ...
Prushoth Vivekanantha   +7 more
wiley   +1 more source

Editorial Commentary: Machine Learning and 300,000 Simulations Confirm That Fragility Reflects the P Value, Not Trial Robustness: Taking Apart a Calculator to Reveal That 2 + 2 Equals 4

open access: yesArthroscopy, EarlyView.
Abstract The fragility index continues to be promoted as a measure of trial robustness despite evidence that it is little more than statistical significance in a different form. Two misconceptions have been particularly persistent throughout the fragility literature: first, that the fragility index can be directly compared with patients lost to follow ...
Jacob F. Oeding
wiley   +1 more source

Remote Roca: Integrating Data From Archaeological Survey, Remote Sensing and Geophysics in the Hinterland at the Long‐Lasting Mediterranean Site of Rocavecchia (Apulia, Italy)

open access: yesArchaeological Prospection, EarlyView.
ABSTRACT This study presents a multi‐method non‐invasive investigation of an approximately 4‐ha area associated with the long‐occupied coastal settlement of Rocavecchia (Apulia, southern Italy), situated between the prehistoric fortified peninsula and the Hellenistic‐Messapian walls.
Giuseppe Guarino   +3 more
wiley   +1 more source

Technology Transfer to Underwater Archaeology: The LAHKE Project at the Submerged Neolithic Site of La Marmotta

open access: yesArchaeological Prospection, EarlyView.
ABSTRACT This document is a report on the field application of non‐invasive geophysical and robotic prospecting methods at the submerged Neolithic site of La Marmotta (Lake Bracciano, Italy), within the LAHKE (LAke Heritage Knowledge and Exploration) project; the study focuses on the practical validation, adaptation and transfer of existing ...
dell' Erba Ramiro   +4 more
wiley   +1 more source

Project MIMIC (Maximizing Implementation of Motivational Incentives in Clinics): preparation phase outcomes of a hybrid type 3 trial. [PDF]

open access: yesImplement Sci Commun
Becker SJ   +6 more
europepmc   +1 more source

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

open access: yesArthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola   +14 more
wiley   +1 more source

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