Results 111 to 120 of about 1,269,624 (326)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

High-Precision Continuation of Periodic Orbits

open access: yesAbstract and Applied Analysis, 2012
Obtaining periodic orbits of dynamical systems is the main source of information about how the orbits, in general, are organized. In this paper, we extend classical continuation algorithms in order to be able to obtain families of periodic orbits with ...
Ángeles Dena   +3 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Development and validation of a nomogram for predicting the risk of poor prognosis in patients with cerebral infarction

open access: yesHeliyon
Objective: To identify factors related to poor prognosis in patients with cerebral infarction (CI) and to construct and validate a personalized prediction model based on these factors.
Zhenfeng Chen   +5 more
doaj   +1 more source

Discourses of Historical Memory (Continuation)

open access: yesДискурс Пи, 2017
In the continuation of the article subject to review will be the methods and means by which social institutions perform the work on deciphering structures of identity of people from other historical periods, which can be applied for the analysis of our ...
K.S. Romanova
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Factors Predicting Treatment Adherence in Outpatients with Cancer-Related Edema: Decision Tree Analysis

open access: yesCancer Management and Research
Yudai Fujimoto,1,2 Yoshimi Yuri,2 Miki Fujii,1 Hironari Tamiya1,3 1Department of Rehabilitation, Osaka International Cancer Institute, Osaka, Japan; 2Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan; 3Department
Fujimoto Y, Yuri Y, Fujii M, Tamiya H
doaj  

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