Results 51 to 60 of about 1,782,235 (304)

Association between social capital and utilization of essential public health services among elderly migrants: a multilevel logistic study based on the 2017 China migrant dynamic survey (CMDS)

BMC Public Health
Background As the number of elderly migrants in China continues to grow, it is necessary to pay closer attention to their health and health services. Some studies have confirmed that social capital plays a significant role in the utilization of health ...
Qi Luo, Xiaolei Chen, Linlin Zhao, Qinghua Hu, Juan Du, Shuang Shao   +5 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Governor\u27s Approval 12/13/1999 [PDF]

, 1999
The continuing problem of how to fund public education remains the most important problem facing the Granite State.
Survey Center, UNH
core   +1 more source

Factors affecting the essential medicine prescribing behavior among general practitioners in Beijing, China: a cross-sectional study with structural equation model

BMC Primary Care
Background The aim of this study is to explore the influence of GPs’information, motivation and behavior skills on EM prescribing behavior in urban and suburban districts.
Xiaolei Chen, Zhengwen Feng, Qi Luo, Hui Li, Shuang Shao, Juan Du   +5 more
doaj   +1 more source

The needs of informal caregivers and barriers of primary care workers toward dementia management in primary care: a qualitative study in Beijing

BMC Family Practice, 2018
Background Informal caregivers of people with dementia in Beijing are increasingly called upon to provide home-based care for their patients due to the increasing number of dementia patients and the shortage of standardized institutional solutions of ...
Meirong Wang, Shuang Shao, Jing Li, Yingjie Liu, Xiaojingyuan Xu, Juan Du   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Challenging the 'New Professionalism': from managerialism to pedagogy? [PDF]

, 2003
In recent years there have been changes made to the conceptualisation of continuing professional development for teachers in both the Scottish and English systems of education.
Alastair McPhee, ArmstrongT., Ball S., BallS., Bottery M., BrunerJ., Carlgren I., Carr D., Christine Forde, Clegg S., ErautM., Fiona Patrick, Flecknoe M., GardnerH., GolemanD., GoodladS., GTCE, Hansen A., Hegarty S., Humes W., Humes W., JensenE., JensenE., Koetsier C., Learning and Teaching Scotland, LezearD., Livingston K., McNally J., McWilliam E., MortimoreP., MortimoreP., Ovens P., Reeves J., ReevesJ., Sachs J., Sachs J., Scoble M., Scott C., Scottish Consultative Council on the Curriculum, Scottish Education Department, Scottish Education Department, Scottish Education Department, Scottish Executive Education Department, Scottish Office Education and Industry Department, Scottish Office Education and Industry Department, StollL., Tomlinson J., Weir D., Wright P.   +48 more
core   +1 more source

EXTRACORPOREAL RENAL SURGERY (LITERATURE REVIEW)

Сибирский онкологический журнал, 2017
Currently, along with the development of gravity blood surgery and transplantation, nephron-sparing surgery has become an established surgical treatment, particularly in situations in which preservation of renal parenchyma is critical.
R. I. Rasulov, V. V. Dvornichenko, A. A. Muratov   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source