Results 81 to 90 of about 203,487 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Continuity of care during long-term care transitions: a scoping review of the Canadian literature

BMC Health Services Research
Background Patients who maintain longitudinal provider-patient relationships experience better overall health outcomes. However, most older adults in Canada lose contact with their family physician when they enter long-term care (LTC) as new providers ...
Augustine Chukwuebuka Okoh, Alfina Shahu, Regis Gu, Henry Siu, Michelle Howard, Ellen Badone, Lawrence Grierson   +6 more
doaj   +1 more source

Clinical outcomes for women who had continuity of care experiences with midwifery students

, 2021
BACKGROUND: Pre-registration midwifery students in Australia are required to engage in a minimum of ten continuity of care experiences (CoCE). Students recruit and gain consent of each woman to provide CoCE under direct supervision of a registered health
Tickle, Nikki, Gamble, Jenny, Creedy, Debra K   +2 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Concepts underlying continuity of care - the system of concepts described in ENV 13940a

Journal of Innovation in Health Informatics, 2002
In 1998, the Technical Committee 'Health Informatics' (TC 251) of CEN (European Committee for Standardisation) set up a specific project team to address aspects of sharing patient-related information needed in the process of care, in order to support ...
François Mennerat, Nick Booth
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Detection of Elementary White Mucosal Lesions by an AI System: A Pilot Study

Oral
Aim: Accurately identifying primary lesions in oral medicine, particularly elementary white lesions, is a significant challenge, especially for trainee dentists.
Gaetano La Mantia, Federico Kiswarday, Giuseppe Pizzo, Giovanna Giuliana, Giacomo Oteri, Mario G. C. A. Cimino, Olga Di Fede, Giuseppina Campisi   +7 more
doaj   +1 more source

Continuity of Care Assessment Within a Vertically Integrated Care Management Organization Before and After COPD-Related Exacerbations

International Journal of COPD, 2021
Morgan Justice Fuoco,1 Richard A Mularski,1 Benjamin Wu,2 Chad Moretz,2 Mary Ann McBurnie,1 Richard H Stanford,2 Phillip Crawford,1 Daniel Gratie,2 Bianca Salas1 1Kaiser Permanente Center for Health Research, Science Programs Department, Portland, OR ...
Fuoco MJ, Mularski RA, Wu B, Moretz C, McBurnie MA, Stanford RH, Crawford P, Gratie D, Salas B   +8 more
doaj  

How unique is continuity of care? A review of continuity and related concepts

, 2011
Background: The concept of ‘continuity of care’ has changed over time and seems to be entangled with other care concepts, for example coordination and integration of care.
Uijen, A.A., W. J. H. M. van den Bosch, van den Bosch, W.J.H.M., Schers, H.J., Schellevis, F.G., Bosch, W.J.H.M. van den, H. J. Schers, A. A. Uijen, F. G. Schellevis   +8 more
core   +1 more source

Women's reports of satisfaction and respect with continuity of care experiences by students: Findings from a routine, online survey

, 2020
BACKGROUND: Pre-registration midwifery students in Australia undertake a minimum of ten continuity of care experiences with childbearing women. However, women are rarely asked to formally evaluate this care by students.
Tickle, Nikki, Gamble, Jenny, Creedy, Debra K   +2 more
core   +1 more source