Results 141 to 150 of about 386,914 (390)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Impacto del seguimiento al alta de Enfermería en Atención Primaria sobre los reingresos hospitalarios tempranos. Estudio observacional longitudinal

Atención Primaria
Resumen: Objetivo: Determinar la proporción de personas en las que se realiza el seguimiento al alta estando indicado.Diseño Estudio observacional longitudinal retrospectivo, con enfoque analítico.
Raquel Sánchez-Ruano, Pedro López-Paterna, César Alfonso García-Hernández, Ricardo Rodríguez-Barrientos, Elvira Herrero-Sanchox, Marcos Pascual-García, Milagros Rico-Blázquez   +6 more
doaj   +1 more source

Challenges of Post-Discharge Follow-up in Psychiatric Patients in Isfahan Farabi Hospital: A Qualitative Study

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Comprehensive discharge program refers to providing education, follow-up and continuity of care. This issue is one of the requirements for the effectiveness of treatment in patients with mental health diseases. This study aimed at
Marzieh Javadi, Mohammad Mahdi Behzadnezhad, Mojtaba Alizade, Nasrin Sharbafchizade, Maryam Yaghoubi   +4 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Experience with health care integration in Bidasoa integrated health organisation: development of the continuity of care unit/Experiencia de integración en la Organización Sanitaria Integrada Bidasoa: desarrollo de la Unidad de Continuidad Asistencial

International Journal of Integrated Care, 2012
Iñaki Berraondo Zabalegui
doaj   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Impact of Continuity of Care on Health Indicators in Patients With Type 2 Diabetes Mellitus in Family Medicine Clinics in Riyadh [PDF]

, 2023
Ghada Hussein, Aljoharah A Al Saud, Ahmad M Siddiqi, Abdallah M. Khasawinah, Ahmad Alenezi, Riham A Mohammed, Yaser Alendijani   +6 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Continuity of care in Swiss cancer patients

, 2018
17. Deutscher Kongress für Versorgungsforschung (DKVF)
Blozik, E, Näpflin, M, Bähler, C, Scherer, M   +3 more
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source