Results 61 to 70 of about 98,858 (265)

Estimation–Calibration of Continuous-Time Non-Homogeneous Markov Chains with Finite State Space

Mathematics
We propose a method for fitting transition intensities to a sufficiently large set of trajectories of a continuous-time non-homogeneous Markov chain with a finite state space.
Manuel L. Esquível, Nadezhda P. Krasii, Gracinda R. Guerreiro   +2 more
doaj   +1 more source

Facilitating Numerical Solutions of Inhomogeneous Continuous Time Markov Chains Using Ergodicity Bounds Obtained with Logarithmic Norm Method

Mathematics, 2020
The problem considered is the computation of the (limiting) time-dependent performance characteristics of one-dimensional continuous-time Markov chains with discrete state space and time varying intensities. Numerical solution techniques can benefit from
Alexander Zeifman, Yacov Satin, Ivan Kovalev, Rostislav Razumchik, Victor Korolev   +4 more
doaj   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

On One Approach to Obtaining Estimates of the Rate of Convergence to the Limiting Regime of Markov Chains

Mathematics
We revisit the problem of the computation of the limiting characteristics of (in)homogeneous continuous-time Markov chains with the finite state space. In general, it can be performed only numerically.
Yacov Satin, Rostislav Razumchik, Alexander Zeifman, Ilya Usov   +3 more
doaj   +1 more source

Revisiting a long‐overlooked skull: Implications for the distribution of Dinodontosaurus brevirostris (Kannemeyeriiformes) in the Brazilian Triassic

The Anatomical Record, EarlyView.
Abstract Dicynodonts (Anomodontia: Dicynodontia) were one of the main groups of terrestrial tetrapods in Permian and Triassic faunas. In Brazil, the genus Dinodontosaurus is one of the most common tetrapod taxon in the Triassic Santa Maria Supersequence. This genus has a complex taxonomic history and is represented in the Triassic of both Argentina and
Julia Lara Rodrigues de Souza, João Lucas Da Silva, Voltaire D. P. Neto, Arielli Fabrício Machado, Juan A. Escobar, Felipe L. Pinheiro   +5 more
wiley   +1 more source

Early evolution of the gular musculature and its innervation in ray‐finned fishes

The Anatomical Record, EarlyView.
Abstract Gular muscles are an important but often overlooked component of cranial anatomy in bony fishes. They are located on the ventral surface of the head and are derived from the mandibular and hyoid arches. We present a comprehensive review of the gular musculature and its innervation across early diverging actinopterygian lineages. By integrating
Aléssio Datovo, Paulo Presti, George Vita, Murilo N. L. Pastana, Luiz A. W. Peixoto   +4 more
wiley   +1 more source

On-the-Fly Computation of Bisimilarity Distances [PDF]

Logical Methods in Computer Science, 2017
We propose a distance between continuous-time Markov chains (CTMCs) and study the problem of computing it by comparing three different algorithmic methodologies: iterative, linear program, and on-the-fly.
Giorgio Bacci, Giovanni Bacci, Kim G. Larsen, Radu Mardare   +3 more
doaj   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Level 2.5 large deviations for continuous time Markov chains with time periodic rates

, 2018
We consider an irreducible continuous time Markov chain on a finite state space and with time periodic jump rates and prove the joint large deviation principle for the empirical measure and flow and the joint large deviation principle for the empirical ...
Bertini, L., Chetrite, R., Faggionato, A., Gabrielli, D.   +3 more
core   +3 more sources

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source