Results 121 to 130 of about 5,228,638 (296)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Continuous Household Survey, 1984

open access: yes, 2004
copyright UK Data Service and data collection copyright owner.The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland.
Policy Planning and Research Unit (Northern Ireland), Central Survey Unit
core   +2 more sources

Continuous Household Survey, 2020-2021

open access: yes
copyright UK Data Service and data collection copyright owner.The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland.
Northern Ireland Statistics and Research Agency (NISRA)
core   +2 more sources

Contemporary Fixed-Duration Treatment Options in the First-Line Setting of Chronic Lymphocytic Leukemia: Perspectives from a Publicly Funded Healthcare System

open access: yesCurrent Oncology
First-line options for chronic lymphocytic leukemia (CLL) are evolving, recently returning to a fixed-duration (FD) approach incorporating regimens such as venetoclax + obinutuzumab, ibrutinib + venetoclax, and soon acalabrutinib + venetoclax ...
Christopher Lemieux   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Continuous Household Survey, 2019-2020

open access: yes
copyright UK Data Service and data collection copyright owner.The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland.
Northern Ireland Statistics and Research Agency (NISRA)
core   +2 more sources

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Enteral nutrition–related hyperglycemia in critical illness: cascade conceptual model and implications for precision nursing—a systematic review

open access: yesFrontiers in Nutrition
BackgroundHyperglycemia is a common complication in critically ill patients receiving enteral nutrition (EN). This review synthesizes evidence on its mechanisms, epidemiology, clinical implications, and nursing management to support precision glycemic ...
Jiani Qian   +7 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

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