Results 151 to 160 of about 357,777 (201)

Continuous manufacturing of extended release tablets via powder mixing and direct compression

International Journal of Pharmaceutics, 2015
The aim of the current work was to explore continuous dry powder mixing and direct compression for manufacturing of extended release (ER) matrix tablets. The study was span out with a challenging formulation design comprising ibuprofen compositions with varying particle size and a relatively low amount of the matrix former hydroxypropyl methylcellulose
Tuomas Ervasti, Simo-Pekka Simonaho, Jarkko Ketolainen, Peter Forsberg, Magnus Fransson, Håkan Wikström, Staffan Folestad, Satu Lakio, Pirjo Tajarobi, Susanna Abrahmsén-Alami   +9 more
openaire   +4 more sources

A Demonstration of Mixing Robustness in a Direct Compression Continuous Manufacturing Process

Journal of Pharmaceutical Sciences, 2017
The purpose of this work was to assess the impact of continuous mixing on tablet critical quality attributes (CQAs) manufactured using a continuous, direct compression process. A 9-run design of experiments (DoE) that bracketed the range of commercially relevant mixer speeds, mixer orientations, and mass flow rates was executed using a formulation ...
Wyatt J. Roth, Ahmad Almaya, Timothy T. Kramer, Jeffrey D. Hofer   +3 more
openalex   +3 more sources

Mapping key process parameters to the performance of a continuous dry powder blender in a continuous direct compression system

Powder Technology, 2020
Abstract This work aims to expand the typical raw material attributes that can successfully be processed on a continuous direct compression line with a particular focus on the continuous dry powder blender. Three grades of Acetaminophen were investigated as model active pharmaceutical ingredients and chosen to span a broad range of material ...
John Palmer, Gavin K. Reynolds, Furqan Tahir, Indrajeetsinh K. Yadav, Elizabeth Meehan, James Holman, Gurjit Bajwa   +6 more
openaire   +3 more sources

Integrated modeling of a continuous direct compression tablet manufacturing process: A production scale case study

Powder Technology, 2019
Abstract A flowsheet model for a continuous direct compression tableting process is developed and applied to process data generated at production scale. The model contains powder feeding, blending and tablet compaction unit operations. The dataset was provided by Merck & Co., Inc., Kenilworth, NJ USA using a GEA ConsiGma™ continuous direct ...
S.C. Galbraith, B. Cha, Z. Huang, S. Park, H. Liu, R.F. Meyer, M.H. Flamm, S. Hurley, F. Zhang-Plasket, S. Yoon   +9 more
openaire   +3 more sources

Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release

Drug Development and Industrial Pharmacy, 2012
Continuous processing is becoming popular in the pharmaceutical industry for its cost and quality advantages.This study evaluated the mechanical properties, uniformity of dosage units and drug release from the tablets prepared by continuous direct compression process.The tablet formulations consisted of acetaminophen (3-30% (w/w)) pre-blended with 0.25%
Maiju Järvinen, Janne Paaso, Marko Paavola, Kauko Leiviskä, Mikko Juuti, Fernando J. Muzzio, Kristiina Järvinen   +6 more
openalex   +5 more sources

100% visual inspection of tablets produced with continuous direct compression and coating

International Journal of Pharmaceutics, 2022
Visual appearance of tablets is an important property for patients. Since the visual appearance is most strongly influenced by the applied coating, this necessitates a high level of process control and homogeneity in the coating process. In recent years, a number of tablet coaters have been developed that can be used in combination with continuous ...
Shirin, Barimani, Rok, Šibanc, Dejan, Tomaževič, Robin, Meier, Peter, Kleinebudde   +4 more
openaire   +2 more sources

Comprehensive review in continuous direct compression process

Journal of Pharmaceutical Investigation
M. Na, Y. S. Lee, Eun‐Sol Ha, Min‐Soo Kim, Heejun Park   +4 more
openalex   +2 more sources

Starch Products as Candidate Excipients in a Continuous Direct Compression Line

Journal of Pharmaceutical Innovation, 2021
Direct compression (DC) remains the most preferred technique to produce tablets, and its effectiveness is directly influenced by raw material attributes. Therefore, the selection of specific grades of excipients to achieve desirable powder flow and compression properties is of importance.
Sonia M. Razavi, Yi Tao, James Scicolone, Tami Morker, Charles Cunningham, Ali Rajabi-Siahboomi, Douglas B. Hausner, Fernando J. Muzzio   +7 more
openaire   +1 more source

Digital twin of a continuous direct compression line for drug product and process design using a hybrid flowsheet modelling approach

International Journal of Pharmaceutics, 2022
Marta Moreno-Benito, Kai T. Lee, Denis Kaydanov, Hugh Verrier, Daniel O. Blackwood, Pankaj Doshi   +5 more
openalex   +3 more sources

Flowsheet modeling of a continuous direct compression process

, 2018
Seongkyu Yoon, Shaun Galbraith, Bumjoon Cha, Yanling Liu   +3 more
openalex   +2 more sources