Results 161 to 170 of about 357,777 (201)
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Pharmaceutical Development and Technology, 2018
Continuous manufacturing techniques are increasingly being adopted in the pharmaceutical industry and powder blending is a key operation for solid-dosage tablets. A modeling methodology involving axial and radial tanks-in-series flowsheet models is developed to describe the residence time distribution (RTD) and blend uniformity of a commercial powder ...
Shaun C, Galbraith +5 more
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Continuous manufacturing techniques are increasingly being adopted in the pharmaceutical industry and powder blending is a key operation for solid-dosage tablets. A modeling methodology involving axial and radial tanks-in-series flowsheet models is developed to describe the residence time distribution (RTD) and blend uniformity of a commercial powder ...
Shaun C, Galbraith +5 more
openaire +2 more sources
Development of a continuous direct compression platform for low-dose drug products
International Journal of Pharmaceutics, 2017In this work a continuous direct compression process was developed for a low-dosed drug product. Each unit operation of the GEA CDC-50 system was thoroughly investigated. This paper aimed to tackle the macroscopic and microscopic blend uniformity challenges inherently associated with continuous direct compression of cohesive and agglomerated APIs ...
B, Van Snick +6 more
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International Journal of Pharmaceutics, 2022
The ongoing transition from batch to continuous manufacturing offers both challenges and opportunities in the field of oral solid dosage form production. In turn, Process Analytical Technology (PAT) offers a path towards the successful deployment of continuous tablet manufacturing in rotary tablet presses.
Juan Pablo, Gallo-Molina +4 more
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The ongoing transition from batch to continuous manufacturing offers both challenges and opportunities in the field of oral solid dosage form production. In turn, Process Analytical Technology (PAT) offers a path towards the successful deployment of continuous tablet manufacturing in rotary tablet presses.
Juan Pablo, Gallo-Molina +4 more
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International Journal of Pharmaceutics, 2021
One of the critical quality attributes of the solid oral dosage forms produced in continuous direct compression operations is the tablet potency. A novel soft sensor comprising of a combination of first principle-based and empirical models has been developed to enable real-time monitoring of blend and tablet potency, and concentrations of other ...
Reza Kamyar +4 more
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One of the critical quality attributes of the solid oral dosage forms produced in continuous direct compression operations is the tablet potency. A novel soft sensor comprising of a combination of first principle-based and empirical models has been developed to enable real-time monitoring of blend and tablet potency, and concentrations of other ...
Reza Kamyar +4 more
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Control of a Continuous Direct Compression Process via a Residence Time Distribution Process Model
, 2016 Frank Witulski
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Journal of Pharmaceutical Sciences, 2018
Continuous manufacturing of tablets has many advantages, including batch size flexibility, demand-adaptive scale up or scale down, consistent product quality, small operational foot print, and increased manufacturing efficiency. Simplicity makes direct compression the most suitable process for continuous tablet manufacturing.
Sayantan, Chattoraj +1 more
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Continuous manufacturing of tablets has many advantages, including batch size flexibility, demand-adaptive scale up or scale down, consistent product quality, small operational foot print, and increased manufacturing efficiency. Simplicity makes direct compression the most suitable process for continuous tablet manufacturing.
Sayantan, Chattoraj +1 more
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International Journal of Pharmaceutics
This feasibility study evaluates a cleaning process designed to avoid the use of detergents and reduce operator exposure to the active pharmaceutical ingredient (API). The continuous manufacturing equipment was cleaned using excipients to displace ibuprofen residues from the system. The cleaning process was performed using 3.0 kg of Prosolv® and 3.0 kg
Dhavalkumar S. Patel +2 more
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This feasibility study evaluates a cleaning process designed to avoid the use of detergents and reduce operator exposure to the active pharmaceutical ingredient (API). The continuous manufacturing equipment was cleaned using excipients to displace ibuprofen residues from the system. The cleaning process was performed using 3.0 kg of Prosolv® and 3.0 kg
Dhavalkumar S. Patel +2 more
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2016 Sixth International Conference on Information Science and Technology (ICIST), 2016
In this paper, it is shown how 2-D continuous compressive sensing (CCS) is used to recovery the complete measurements of a uniform rectangular array from its sparse case. 2-D CCS is implemented by reweighted atomic norm minimization. Based on the recovered data covariance matrix, the 2-D directions of arrival (DOA) are estimated via the Vandermonde ...
Jincheng Lin +3 more
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In this paper, it is shown how 2-D continuous compressive sensing (CCS) is used to recovery the complete measurements of a uniform rectangular array from its sparse case. 2-D CCS is implemented by reweighted atomic norm minimization. Based on the recovered data covariance matrix, the 2-D directions of arrival (DOA) are estimated via the Vandermonde ...
Jincheng Lin +3 more
openaire +1 more source
International Journal of Minerals, Metallurgy, and Materials, 2015
The dynamic recrystallization (DRX) behavior of continuous columnar-grained (CCG) CuNi10Fe1Mn alloy was investigated by hot compression along the solidification direction (SD) and perpendicular to the solidification direction (PD). Specimens were compressed to a true strain of 0.8 at temperatures ranging from 25°C to 900°C and strain rates ranging from
Yong-kang Liu +2 more
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The dynamic recrystallization (DRX) behavior of continuous columnar-grained (CCG) CuNi10Fe1Mn alloy was investigated by hot compression along the solidification direction (SD) and perpendicular to the solidification direction (PD). Specimens were compressed to a true strain of 0.8 at temperatures ranging from 25°C to 900°C and strain rates ranging from
Yong-kang Liu +2 more
openaire +1 more source