Results 31 to 40 of about 728,067 (268)

Characterization of Amorphous Solid Dispersion of Pharmaceutical Compound with pH-Dependent Solubility Prepared by Continuous-Spray Granulator

Pharmaceutics, 2019
A continuous-spray granulator (CTS-SGR) is a one-step granulation technology capable of using solutions or suspensions. The present research objectives were, (1) to reduce the manufacturing operations for solid dosage formulations, (2) to make amorphous ...
Ryoma Tanaka, Yusuke Hattori, Yukun Horie, Hitoshi Kamada, Takuya Nagato, Makoto Otsuka   +5 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Diels–Alder reactions of myrcene using intensified continuous-flow reactors

Beilstein Journal of Organic Chemistry, 2017
This work describes the Diels–Alder reaction of the naturally occurring substituted butadiene, myrcene, with a range of different naturally occurring and synthetic dienophiles.
Christian H. Hornung, Miguel Á. Álvarez-Diéguez, Thomas M. Kohl, John Tsanaktsidis   +3 more
doaj   +1 more source

Hölder Continuity of Random Processes [PDF]

Journal of Theoretical Probability, 2007
17 ...
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Beilstein Journal of Organic Chemistry, 2015
The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities.
Marcus Baumann, Ian R. Baxendale
doaj   +1 more source

Continuous, Lateralized Auditory Stimulation Biases Visual Spatial Processing

Frontiers in Psychology, 2020
Sounds in our environment can easily capture human visual attention. Previous studies have investigated the impact of spatially localized, brief sounds on concurrent visuospatial attention.
Ulrich Pomper, Rebecca Schmid, Ulrich Ansorge, Ulrich Ansorge   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

From Batch to Continuous Small-Scale Production of Particles: Mixer Design Methodology for Robust Operation

Crystals
Layered double hydroxides (LDHs) are a vital tool in many different areas, such as drug delivery, catalysis, anion exchange (materials), polymer processing, etc. Conventionally, LDHs are synthesized in a batch process that consists of particle generation
Stefan Höving, Philipp Ronnewinkel, Norbert Kockmann   +2 more
doaj   +1 more source