Results 241 to 250 of about 17,177,934 (283)

Compressive learning scaffolds higher-order network structure to enhance human knowledge acquisition. [PDF]

Nat Commun
Ren X, Wang M, Qin T, Fang F, Li A, Luo H.   +5 more
europepmc   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Bayesian Network Meta-Analysis With One or Two Continuous Outcomes Measured at Multiple Time Points Using Gaussian Random Walks With Drift. [PDF]

Stat Med
Cheng PS, da Costa BR, Tomlinson G.
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

A Three-Layer Adaptive Kalman Filter Approach for Multi-Source Time Fusion Using Temperature-Compensated Oscillators with GNSS and eLoran Backup. [PDF]

Sensors (Basel)
Yuan Z, Gao S, Li P, Zhang S.
europepmc   +1 more source

Nonparametric Assessment of the Calibration of Individualized Treatment Effects. [PDF]

Stat Med
Sadatsafavi M, Hoogland J, Debray TPA, Petkau J.   +3 more
europepmc   +1 more source

Digital Health Technology for Improving Physical Function in Adults With Chronic Heart Failure: Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

J Med Internet Res
Meng Z, Li J, Yang J, Lin Y, Zhang Q, Wei L, Zhou X.   +6 more
europepmc   +1 more source

Stability of movement by a multi-element system: drifts and random walk within and orthogonal to the uncontrolled manifold during multi-finger force production. [PDF]

Exp Brain Res
De SD, Latash ML.
europepmc   +1 more source

An interpretable stacked ensemble framework for evaluating respiratory rehabilitation outcomes under traditional Chinese medicine-integrated care: a multicenter retrospective cohort study. [PDF]

Front Med (Lausanne)
Li Y, Wu Z.
europepmc   +1 more source

Comparative analysis of wearable-derived gait features with intrinsic risk indicators for fall risk prediction in older adults. [PDF]

Sci Rep
Wu P, Fang J, Wang J, Guan Z, Zhang Y, Zhang H.   +5 more
europepmc   +1 more source