Results 81 to 90 of about 17,177,934 (283)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Interplay between Non-Markovianity of Noise and Dynamics in Quantum Systems
Entropy, 2023 The non-Markovianity of open quantum system dynamics is often associated with the bidirectional interchange of information between the system and its environment, and it is thought to be a resource for various quantum information tasks.
Arzu Kurt
doaj +1 more source
Quenched invariance principles for random walks and elliptic diffusions in random media with boundary [PDF]
, 2014 Via a Dirichlet form extension theorem and making full use of two-sided heat kernel estimates, we establish quenched invariance principles for random walks in random environments with a boundary.
Croydon, David A. +5 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Mathematics, 2022 This paper considers a method of stochastic solution to the anomalous diffusion equation with a fractional derivative with respect to both time and coordinates.
Viacheslav V. Saenko +4 more
doaj +1 more source
Continuous-time random walks on bounded domains
Physical Review E, 2011 A useful perspective to take when studying anomalous diffusion processes is that of a continuous-time random walk and its associated generalized master equation. We derive the generalized master equations for continuous-time random walks that are restricted to a bounded domain and compare numerical solutions with kernel-density estimates of the ...
Nathanial, Burch, R B, Lehoucq
openaire +3 more sources
Saddlepoint approximation to the distribution of the total distance of the von Mises-Fisher continuous time random walk [PDF]
, 2018 This article considers the random walk over Rp with any p ≥ 2, where a particle starts at the origin and progresses stepwise with fixed step lengths and von Mises–Fisher distributed step directions.
R. Gatto, Gatto, Riccardo
core +3 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The Role of Anomalous Transport in Long‐Term, Stream Water Chemistry Variability
Geophysical Research Letters, 2023 We investigate the occurrence of anomalous (non‐Fickian) transport in an hydrological catchment system at kilometer scales and over a 36‐year period. Using spectral analysis, we examine the fluctuation scaling of long‐term time series measurements of a ...
Marco Dentz +3 more
doaj +1 more source