Results 171 to 180 of about 16,132,005 (307)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Improving financial protection and access: Managing co-payments for outpatient prescription medicines through digital technologies in Estonia. [PDF]

Health Policy Open
Kasekamp K, Habicht T, Mathauer I.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Reshaping Smart Pharmacy in TCM Hospitals via High-Reliability Organization Theory. [PDF]

J Multidiscip Healthc
Cai T, Yao W, Yan X, Weng Y, Zhang J, Wang L, Wang W, Zhan W, Wang J, Jin J, Shi Z.   +10 more
europepmc   +1 more source

The use of Miniex as a continuous feedback tool for a family and community medicine resident in internship at primary health care

, 2018
Introdução: A consulta é central no trabalho do médico de família e comunidade. A avaliação da performance do residente e discussões acerca da adequada condução deve ser estimulada. Objetivo: Discutir sobre o uso do Miniex para avaliação sequenciada de performance do residente durante consultas.
Mendes, Artur Oliveira, Viveiros, Luara Brandão   +1 more
openaire   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

The FMB scale: a multifactorial metric to assess the driving hazard of medicines beyond the DRUID system. [PDF]

Ther Adv Drug Saf
Borja Ripoll S, Traver V, Franco L, Ballester T, Alvado Ú, Soriano R, Garate P, Mocholí F.   +7 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Horizon scanning at EMA: preparing for the medicines of the future. [PDF]

Front Med (Lausanne)
Correia PD, Cordo' V, Blanquie O, Tognana E, Balourdas DI, Ziogas C, Ehmann F.   +6 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source