Results 131 to 140 of about 845,308 (362)

Serial discontinuity in naturally alternating forest and floodplain habitats of a Michigan (USA) stream based on physicochemistry, benthic metabolism, and organismal assemblages

Journal of Freshwater Ecology, 2018
We tested the response of several different water quality metrics at 6 sites along a 4-km alternating forest (canopied) and floodplain (non-canopied) reach of the East Branch of the Black River, an undisturbed northern Lower Michigan trout stream, during
David C. Houghton, Benjamin A. Albers, William T. Fitch, Eleanor G. Smith, Mary Clare Smith, Erich M. Steger   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CRUSER Warfare Innovation Continuum (WIC) Workshop 2017

, 2017
2017-09 Warfare Innovation WorkshopWarfare Innovation Continuum ...

core  

Contractibility of the hyperspace of meager subcontinua, two examples

Applied General Topology
Given a metric continuum X, the hyperspace of meager subcontinua of X, denoted by M(X), is the collection of all subcontinua of X with empty interior. Answering questions by Norberto Ordo˜nez, in this paper we construct two dendroids showing that there ...
Alejandro Illanes, Diego Alexander Ramírez Angarita   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On Pointwise Smooth Dendroids

Revista Integración, 2022
This is a survey paper on dendroids, smooth dendroids, and mainly on pointwise smooth dendroids based on the work of J. J. Charatonik and C. Eberhart (dendroids and smooth dendroids) and S. T. Czuba (pointwise smooth dendroids).
Sergio Macías
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Some discrete approaches to continuum economies [PDF]

, 1996
Given the preferences of the agents of a continuum economy, we define the average and unanimous preference. This allow us to consider several sequences of economies, in which only a finite number of different agents' characteristics can be distinguished.
Moreno García, Emma, Núñez, Carmelo, Hervés Beloso, Carlos   +2 more
core  

September 2022 Workshop Quick Look

, 2022
Prepared by Lyla Englehorn, NPS Faculty Associate – Research for Col Randy Pugh USMC, NWSI Director; CAPT Jeff Kline USN retired, NWSI Warfare Innovation Continuum Director and Professor of the Practice NPS Operations Research Department; and Dr.
Englehorn, Lyla
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source