Results 141 to 150 of about 59,579 (312)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
An automatic chinese font library generation method by modifying vector contour curves
, 2014 Recently, the information leaking problem of important a per-based documents has become more and more serious, which is caused by scanning, copying and photographing methods.
Wei Guo +5 more
core +1 more source
Jixie chuandong, 2013 The parametric drawing program of disc cam is discussed based on Visual C++ in SolidWorks.It re-alizes the parameter input,calculation and automatic generation of contour curve in the cam design.For straight moving part,it uses the template model that ...
王晨, 王宗彦, 吴淑芳, 秦慧斌
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Efficient generation of contour trees in three dimensions
, 2000 Many scientific fields generate data in three-dimensional space. These fields include fluid dynamics, medical imaging, and X-ray crystallography. In all contexts, a common difficulty exists: how best to represent the data visually and analytically ...
Carr, Hamish
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
"Metodologia integrada para a medição da forma geometrica, deslocamentos, deformações e tensões em superficies não planas atraves da holografia eletronica" [PDF]
, 1994 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnologicoA holografia eletrônica tem sido usada na medição de campos de deslocamentos, deformações e tensões em superfícies planas.
Assuiti, Carlos Henrique
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source