Results 61 to 70 of about 3,639,802 (341)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

滚子摆动从动件盘状凸轮轮廓曲线的确定

open access: yesJixie chuandong, 2007
The discal cam contour line with the driven part of roller swing is used in the double piston pump transport mechanism,By analyzing the working principal and the movements of this pump transport mechanism,the contour line of the compensatory cam ...
阮晓光, 蔡安江
doaj  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

The trochanteric double contour is a valuable landmark for assessing femoral offset underestimation on standard radiographs: a retrospective study

open access: yesBMC Musculoskeletal Disorders, 2021
Background Inaccurate projection on standard pelvic radiographs leads to the underestimation of femoral offset—a critical determinant of postoperative hip function—during total hip arthroplasty (THA) templating.
Stefan Blümel   +5 more
doaj   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Application of Geographic Information System and Automated Guidance System in Optimizing Contour and Terrace Farming

open access: yesAgriculture, 2018
Farming contour and terrace fields using automated guidance systems with global navigation satellite system (GNSS) receivers requires appropriate geographic features for effective guidance and soil and water conservation.
Wenxuan Guo
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Line generalization evaluation on contour map generated from SRTM and ASTER GDEM

open access: yesJournal of Applied Geospatial Information, 2018
A contour map is one of many layers that composed Informasi Geospasial Dasar (IGD), which according to Act. No 4 2011 serves as a reference for any thematic map.
Totok Wahyu Wibowo
doaj  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

The role of sensory uncertainty in simple contour integration.

open access: yesPLoS Computational Biology, 2020
Perceptual organization is the process of grouping scene elements into whole entities. A classic example is contour integration, in which separate line segments are perceived as continuous contours.
Yanli Zhou, Luigi Acerbi, Wei Ji Ma
doaj   +1 more source

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