Results 81 to 90 of about 3,639,802 (341)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Geometric feature enhanced line segment extraction from large-scale point clouds with hierarchical topological optimization

International Journal of Applied Earth Observations and Geoinformation, 2022
As the most common primitives, line segments play an essential role in the vectorized reconstruction of artificial scenes. In this paper, a geometric feature enhanced line extraction method with Hierarchical Topological Optimization is proposed to ...
Zongtian Hu, Chi Chen, Bisheng Yang, Zhiye Wang, Ruiqi Ma, Weitong Wu, Wenlu Sun   +6 more
doaj  

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Image Interpolation with Geometric Contour Stencils

Image Processing On Line, 2011
We consider the image interpolation problem where given an image vm,n with uniformly-sampled pixels vm,n and point spread function h, the goal is to find function u(x,y) satisfying vm,n = (h*u)(m,n) for all m,n in Z.
Pascal Getreuer
doaj   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

High-Resolution Algorithm for Image Segmentation in the Presence of Correlated Noise

Journal of Electrical and Computer Engineering, 2010
Multiple line characterization is a most common issue in image processing. A specific formalism turns the contour detection issue of image processing into a source localization issue of array processing.
Haiping Jiang, Salah Bourennane, Caroline Fossati   +2 more
doaj   +1 more source

Detection of Contour Lines for Particle Image.

KAGAKU KOGAKU RONBUNSHU, 1993
画像中の粒子像を, Marr-Hildrethフィルターを用いて, 背景から正しく取り出す方法を開発した.まず重なりのない2粒子像を使って, 各粒子の輪郭線を別々に得るためのフィルターパラメー夕の調整について調べた結果, オフ領域半径がある限界値を超えないように, オペレータ中のガウス関数の標準偏差σを選ぶ必要があることがわかった.またこのオフ領域半径の上限値は画像中の粒子間距離, 粒子像エッジ幅, 粒子半径との間に線形関係があることも明らかにした.さらにピントの合っている粒子像と合っていない粒子像の判別を, 得られた輪郭線上で濃度勾配の平均値の閾値判定によって行う方法を示した.これらの方法によってピントの合った粒子像の輪郭線が精度良く得られることを確かめた.
Fumihiro Koizumi, Hirokazu Nishitani, Shigeharu Toyoda, Eiichi Kunugita   +3 more
openaire   +2 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Extraction of Terrain Feature Lines from Elevation Contours Using a Directed Adjacent Relation Tree

ISPRS International Journal of Geo-Information, 2018
The extraction of terrain feature lines is an important yet challenging problem in the processing and usage of contour lines. Most research has focused on identifying terrain feature points by using methods such as the Douglas–Peucker (D–P ...
Chengming Li, Peipei Guo, Pengda Wu, Xiaoli Liu   +3 more
doaj   +1 more source