Results 31 to 40 of about 14,292 (227)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Hele-Shaw flow on weakly hyperbolic surfaces
, 2004 We consider the Hele-Shaw flow that arises from injection of two-dimensional fluid into a point of a curved surface. The resulting fluid domains have and are more or less determined implicitly by a mean value property for harmonic functions.
Hedenmalm, Haakan, Olofsson, Anders
core +1 more source
The renormalization transformation for two-type branching models [PDF]
, 2007 This paper studies countable systems of linearly and hierarchically interacting diffusions taking values in the positive quadrant. These systems arise in population dynamics for two types of individuals migrating between and interacting within colonies ...
Dawson, Don A. +4 more
core +4 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
BarekengNumerical methods are crucial for solving ordinary differential equations (ODEs) that frequently arise in various fields of science and engineering. This study compares three numerical methods: the fourth-order Runge-Kutta method (RK4), the fourth-order ...
Marsudi Marsudi, Isnani Darti
doaj +1 more source
Avoiding bias in reconstructing the largest observable scales from partial-sky data
, 2011 Obscuration due to Galactic emission complicates the extraction of information from cosmological surveys, and requires some combination of the (typically imperfect) modeling and subtraction of foregrounds, or the removal of part of the sky.
Andrew Pontzen +3 more
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
NuSTAR Detection Of A Cyclotron Line In The Supergiant Fast X-ray Transient IGR J17544-2619 [PDF]
, 2014 We present NuSTAR spectral and timing studies of the Supergiant Fast X-ray Transient (SFXT) IGR J17544-2619. The spectrum is well-described by a ~1 keV blackbody and a hard continuum component, as expected from an accreting X-ray pulsar.
Bellm, Eric +18 more
core +8 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source