Results 51 to 60 of about 14,310 (235)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Hele-Shaw flow on weakly hyperbolic surfaces
, 2004 We consider the Hele-Shaw flow that arises from injection of two-dimensional fluid into a point of a curved surface. The resulting fluid domains have and are more or less determined implicitly by a mean value property for harmonic functions.
Hedenmalm, Haakan, Olofsson, Anders
core +1 more source
, 2013 We investigate the representation of homogeneous, symmetric means in the form M(x,y)=\frac{x-y}{2f((x-y)/(x+y))}. This allows for a new approach to comparing means. As an example, we provide optimal estimate of the form (1-\mu)min(x,y)+ \mu max(x,y)
Witkowski, Alfred
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Structure of solutions of the Skyrme model on three-sphere. Numerical results
, 2002 The hedgehog Skyrme model on three-sphere admits very rich spectrum of solitonic solutions which can be encompassed by a strikingly simple scheme. The main result of this paper is the statement of the tripartite structure of solutions of the model and ...
Bizon P +6 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
BarekengNumerical methods are crucial for solving ordinary differential equations (ODEs) that frequently arise in various fields of science and engineering. This study compares three numerical methods: the fourth-order Runge-Kutta method (RK4), the fourth-order ...
Marsudi Marsudi, Isnani Darti
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source