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This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen +7 more
wiley +1 more source
Abstracts : 11(th) European Congress of Trauma and Emergency Surgery May 15-18, 2010 Brussels, Belgium. [PDF]
europepmc +1 more source

