Results 121 to 130 of about 292,409 (340)

Hormonal contraceptives and EEG-biomarkers of antidepressant treatment response

open access: gold, 2023
Amanda Krog Juvik   +6 more
openalex   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen   +8 more
wiley   +1 more source

Contraceptive Utilization and Unmet Need for Contraception Among Women Undergoing Treatment for Tuberculosis in Addis Ababa, Ethiopia: a Cross-Sectional Study

open access: yesOpen Access Journal of Contraception, 2022
Semaria Solomon,1,* Berhanu Yitayew,2,* Abebaw Kebede3 1Department of Microbiology, Immunology and Parasitology, St. Paul’s Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia; 2College of Health Science, Debre Berhan University ...
Solomon S, Yitayew B, Kebede A
doaj  

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Beyond denomination: The relationship between religion and family planning in rural Malawi [PDF]

open access: yes
Despite the centrality of religion and fertility to life in rural Africa, the relationship between the two remains poorly understood. The study presented here uses unique integrated individual- and congregational-level data from rural Malawi to examine ...
Jenny Trinitapoli, Sara Yeatman
core  

Adolescent contraception [PDF]

open access: yesCanadian Medical Association Journal, 2021
Rosenthal, Margot A.   +1 more
openaire   +2 more sources

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

open access: yesAdvanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao   +13 more
wiley   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu   +6 more
wiley   +1 more source

Discontinuation of long-acting reversible contraceptive methods and associated factors among reproductive-age women in Shashemene town, Oromia, Ethiopia

open access: yesFrontiers in Global Women's Health
BackgroundThe early termination of long-acting reversible contraceptives (LARCs) raises issues for the healthcare system and has the potential to affect public health.
Fikru Letose   +3 more
doaj   +1 more source

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