Results 71 to 80 of about 3,161,306 (342)

Asymmetric information, self-selection and pricing of insurance contracts: the simple no-claims case [PDF]

, 2013
This paper presents an optional bonus-malus contract based on a pri-ori risk classification of the underlying insurance contract. By inducing self-selection, the purchase of the bonus-malus contract can be used as a screening device.
Donnelly, Catherine, Englund, Martin, Nielsen, Jens Perch, Tanggaard, Carsten   +3 more
core   +2 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Development and Field Validation of Lidocaine-Loaded Castration Bands for Bovine Pain Mitigation

Animals, 2020
Castration is among the most common management procedures performed in the dairy and beef cattle industries and is mainly performed by surgery or elastic banding.
James W. Saville, Joseph A. Ross, Tyler Trefz, Crystal Schatz, Heather Matheson-Bird, Brenda Ralston, Ori Granot, Karin Schmid, Richard Terry, Nicholas D. Allan, Jeremy E. Wulff, Merle Olson   +11 more
doaj   +1 more source

The Social Contract and Dispute Resolution: The Transformation of the Social Contract in the United States Workplace and the Emergence of New Strategies of Dispute Resolution [PDF]

, 2003
In recent years, a significant amount of public and academic attention has been devoted to the unravelling of the so-called \u27New Deal\u27 social contract and the emergence of a new social contract between workers and employers in the United States of ...
Lipsky, David B, Seeber, Ronald L
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Specialist in Procurement as the Owner of the Public Procurement Process

Управленческое консультирование, 2018
This article proposes recommendations on how to organize the procurement process for state and municipal customers based on the Deming-Schuhart principle (the PDCA cycle).
Aleksey Evgenevich Kuzmin, Pavel Nikolayevich Filey   +1 more
doaj   +1 more source

The Richness of Contract Theory [PDF]

, 1999
This essay is a review of The Richness of Contract Law: An Analysis and Critique of Conemporary Theories of Contract Law by Robert A. Hillman (1997). Throughout the book, Hillman offers a number of useful insights about various issues of contract law and
Barnett, Randy E
core   +3 more sources

Revisiting Path Contraction and Cycle Contraction

Journal of Computer and System Sciences
The Path Contraction and Cycle Contraction problems take as input an undirected graph $G$ with $n$ vertices, $m$ edges and an integer $k$ and determine whether one can obtain a path or a cycle, respectively, by performing at most $k$ edge contractions in $G$. We revisit these NP-complete problems and prove the following results. Path Contraction admits
Krithika, R., Malu, V. K. Kutty, Tale, Prafullkumar   +2 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Microblade Technology in Quartz during the Mesolithic in Eastern Middle Sweden

Current Swedish Archaeology, 2008
Thc authors present a material that has previously not been given much attcntion : microblades and microblade cores of quartz from eastern middle Sweden. The focus is on the technology. core types, geographical distribution and dating. The debate on how
Fredrik Molin, Roger Wikell
doaj   +1 more source