Results 71 to 80 of about 469,428 (249)
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Quantum Deformations and Superintegrable Motions on Spaces with Variable Curvature
Symmetry, Integrability and Geometry: Methods and Applications, 2007 An infinite family of quasi-maximally superintegrable Hamiltonians with a common set of (2N-3) integrals of the motion is introduced. The integrability properties of all these Hamiltonians are shown to be a consequence of a hidden non-standard quantum sl(
Orlando Ragnisco +3 more
doaj
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Arquivos Brasileiros de CardiologiaResumo A Ranolazina (RANO), conhecida na clínica como Ranexa, é um fármaco que previne a arritmia cardíaca através da inibição da corrente de sódio tardia (INaT).
Victor Martins Miranda +2 more
doaj +1 more source
Definable and Contractible Contracts [PDF]
Econometrica, 2012 This paper analyzes Bayesian normal form games in which players write contracts that condition their actions on the contracts of other players. These contracts are required to be representable in a formal language. This is accomplished by constructing contracts which are definable functions of the Godel code of every other player's contract. We provide
openaire +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
A note regarding “contractibility”,“contractibility with respect to” and“contractibility in”
Revista IntegraciónEn este artículo presentamos, entre otras cosas, un estudio comparativo entre los conceptos de contractibilidad, contractibilidad con respecto a y contractibilidad en, aplicados tanto en espacios topológicos como en hiperespacios de continuos. Uno de los objetivos es precisar y corregir ciertas afirmaciones que aparecen en algunos trabajos donde estos ...
Félix Capulín +2 more
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Journal of Philosophical Logic, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source