Results 81 to 90 of about 1,413,634 (303)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
A New Existence and Uniqueness Theorem for Continuous Games [PDF]
This paper derives a general sufficient condition for existence and uniqueness in continuous games using a variant of the contraction mapping theorem applied to mapping from a subset of the real line on to itself.
Seamus Hogan
core
Effect of the contraction ratio upon viscoelastic fluid flow in three-dimensional square-square contractions [PDF]
, 2011 In this work we investigate the laminar flow through square–square sudden contractions with various contraction ratios (CR¼2.4, 4,8and12), using a Newtonian fluid and a shear-thinning viscoelastic fluid.
Sousa, P.C. +3 more
core +3 more sources
Journal of Inequalities and ApplicationsIn this paper, we introduce two types of weak enriched contractions, namely weak enriched F $\mathcal{F}$ -contraction, weak enriched F ′ $\mathcal{F^{\prime}}$ -contraction, and k-fold averaged mapping based on Kirk’s iterative algorithm of order k. The
Mi Zhou, Naeem Saleem, Mujahid Abbas
doaj +1 more source
MathematicsThis paper introduces the Contraction Mapping Optimizer (CMO), a population-based optimizer whose update rule is derived directly from the Banach fixed-point theorem rather than from a biological or physical metaphor, and for which global convergence is ...
Hana Fathi +3 more
doaj +1 more source
Optimal Linear Biased Estimation Based on Generalized Contraction Mapping
IEEE Access, 2018 Estimation methods are generalized in this paper by the idea of “scalar-vector-matrix”. A generalized contraction mapping (GCM) framework is proposed for searching the optimal linear biased estimation.
Zhangming He +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
The cycle contraction mapping theorem [PDF]
This report lays the foundation for a theory of total correctness for programs not based upon termination. The Cycle Contraction Mapping Theorem is both an extension of Wadge's cycle sum theorem for Kahn data flow and a generalisation of Banach's ...
Matthews, Stephen G.
core
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source