Results 61 to 70 of about 225,421 (305)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Repeatability of corticospinal and spinal measures during lengthening and shortening contractions in the human tibialis anterior muscle [PDF]

, 2012
Elements of the human central nervous system (CNS) constantly oscillate. In addition, there are also methodological factors and changes in muscle mechanics during dynamic muscle contractions that threaten the stability and consistency of transcranial ...
Hortobágyi, Tibor, Tallent Jamie, Tibor Hortobágyi, Howatson, Glyn, Hortobagyi, Tibor; id_orcid, Goodall Stuart, French, Duncan N., St Clair Gibson Alan, French Duncan N., Duncan N French, Alan St Clair Gibson, Tallent, Jamie, St Clair Gibson, Alan, Howatson Glyn, French, Duncan, Goodall, Stuart, Glyn Howatson, Stuart Goodall, Jamie Tallent, Gibson, Alan St Clair, Hortobágyi Tibor   +20 more
core   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

A Comparative Study of the Effect of Commonly Used Pesticides on Cervical Contractions in Pregnant Cows, In Vitro

Toxics
Organochlorine insecticides (DDTs), organophosphate insecticides (malathion), carbamate insecticides (carbaryl and thiram), pyrethroid (cypermethrin and fenvalarate) insecticides, and herbicides (glyphosate and atrazine) were selected for this study ...
Michal Hubert Wrobel
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multivalued Contraction Fixed-Point Theorem in b-Metric Spaces

Mathematics
The authors explore fixed-point theory in b-metric spaces and strong b-metric spaces. They wish to prove some new extensions of the Covitz and Nadler fixed-point theorem in b-metric spaces. In so doing, they wish to answer a question proposed by Kirk and
Bachir Slimani, John R. Graef, Abdelghani Ouahab   +2 more
doaj   +1 more source

β-Citronellol, an alcoholic monoterpene with inhibitory properties on the contractility of rat trachea [PDF]

Brazilian Journal of Medical and Biological Research, 2015
β-Citronellol is an alcoholic monoterpene found in essential oils such Cymbopogon citratus (a plant with antihypertensive properties). β-Citronellol can act against pathogenic microorganisms that affect airways and, in virtue of the popular use of β ...
T.B. Vasconcelos, H.V. Ribeiro-Filho, L.T. Lucetti, P.J.C. Magalhães   +3 more
doaj   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Working the contract [PDF]

Proceedings of the 19th Australasian conference on Computer-Human Interaction: Entertaining User Interfaces, 2007
This paper presents data and analysis from a long term ethnographic study of the design and development of an electronic patient records system in a UK hospital Trust. The project is a public private partnership (PPP) between the Trust and a US based software house (OurComp) contracted to supply, configure and support their customizable-off-the-shelf ...
David B. Martin 0001, Rob Procter, John Mariani, Mark Rouncefield   +3 more
openaire   +2 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source