Results 91 to 100 of about 470,308 (293)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Better Auditing for Better Contracting: Eight Recommendations to Reform the Defense Contract Audit Agency and Other Federal Government Audit [PDF]

open access: yes, 2012
Examines why the DCAA's audits of government contractors sometimes fail. Proposes reforms to strengthen oversight, including giving auditors authority to subpoena contractor records and shifting from limited to risk-based audits and random ...
Pratap Chatterjee
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

THE DOMESTIC MARKET OF HOUSING SERVICES: ASSESSMENT, CHARACTERISTICS AND PROBLEMS OF DEVELOPMENT

open access: yesВестник университета, 2019
The article analyzes the competition of the domestic market housing services, showing the modern features of its formation, revealed problems of its development and control over the provision of housing services.
A. Nagaev
doaj  

What Works? How Federal Contractors are Implementing Section 503: Executive Summary [PDF]

open access: yes, 2018
This survey is part of a larger project entitled “Initial Impact of Section 503 Rules: Identifying Effective Employer Practices and Trends in Disability Violations among Federal Contractors” funded by the US Department of Labor, Chief Evaluation Office ...
Bruyere, Susanne M, Dr.   +1 more
core   +1 more source

Evaluation of a Participatory Ergonomics Intervention in Small Commercial Construction Firms [PDF]

open access: yes, 2016
BACKGROUND: Work-related musculoskeletal disorders (WMSD) among construction workers remain high. Participatory ergonomics (PE) interventions that engage workers and employers in reducing work injury risks have shown mixed results.
Albers   +47 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

(In)equitable Subrogation: The Federal Circuit’s Irrational and Unworkable Progress Payment Framework in Balboa [PDF]

open access: yes, 2016
American taxpayers spend more than $100 billion per year on federal construction projects. Yet massive construction delays, huge budget overruns, and unorganized contractors increase the cost of construction for the federal government.
Hawkins, Will F.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Measuring transaction costs: from theory to practice

open access: yesХабаршысы. Экономика сериясы, 2019
The article deals with the key concept of modern institutional theory – transaction costs. Currently, the study and study of the concepts of transactions and transaction costs is given important attention. Moreover, the constantly changing conditions and
Turchenko A.A.
doaj  

Home - About - Disclaimer - Privacy