Results 131 to 140 of about 109,343 (299)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Idaho Contractors Board Board Meeting Minutes
, 2016 Idaho State Contractors Board minutes for Feb ...
Occupational Licenses, Idaho Bureau of, State Contractors Board;
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Construction Contractors Board
, 2020 Title from PDF caption (viewed on October 30, 2020).Covers OCLC #1202421854 and OCLC #1199366629.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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The contractor–subcontractor relationship: the general contractor’s view
, 2008 Subcontractors play a significant role in the Palestinian construction industry. The relationship between the general contractor and subcontractors is one of the keys to any successful construction project. Despite this importance, little information is available about the actual working relationship which exists between general contractors and ...
Enshassi, Adnan, Medoukh, Zohair
openaire
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Security of payment in Malaysian construction industry: issues on sub-contract's direct payment [PDF]
In Malaysia, sub-contractors have to bear with the current structure of payment mechanisms in the standard forms of contract, which are payment upon certification, direct payment from the employer, and contingent or conditional payment.
Supardi, Azizan, Adnan, Hamimah
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State-level paid sick leave: impacts of policy design on access by immigrant workers. [PDF]
Health Aff SchLuo Z +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source