Results 51 to 60 of about 1,724,251 (331)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

İradeyi İfade Etmede Halin Delaletinin Etkisi (Mali Muamelat Örneği)

Eskişehir Osmangazi Üniversitesi İlahiyat Fakültesi Dergisi, 2020
Kişisel irade gizli bir şeydir. Ancak şer’i bir etki yaratma açısından bu iradenin harici bir göstergeyle ifade edilmesi gerekmektedir. Bu ifade asıl olarak lafız yoluyla gerçekleşmektedir.
İbrahim ALBAKKAR, Nader A. M. FALYOUNA   +1 more
doaj  

Contract-Based Design of Embedded Systems Integrating Nominal Behavior and Safety

Complex Systems Informatics and Modeling Quarterly, 2015
The distributed design process for safety-critical embedded systems has become an increasingly difficult challenge: Electronic Control Units (ECUs) in vehicles, for instance, participate in many vehicle functions, while each vehicle function, in turn, is
Bernhard Kaiser, Raphael Weber, Markus Oertel, Eckard Böde, Behrang Monajemi Nejad, Justyna Zander   +5 more
doaj   +1 more source

Matching ecological transition and food security in the cereal sector: The role of farmers' preferences on production contracts

Frontiers in Sustainable Food Systems, 2023
IntroductionUnder an increasing demand from citizen and public institutions, agri-food supply chains are requested to comply with stringent environmental requirements. Moreover, new sources of uncertainty related to pandemic and geo-political turbulences
Stefano Ciliberti, Angelo Frascarelli, Gaetano Martino   +2 more
doaj   +1 more source

Bonus Pools and the Informativeness Principle [PDF]

, 2013
Previous work on moral-hazard problems has shown that, under certain conditions, bonus contracts create optimal individual incentives for risk-neutral workers.
Imhof, Lorens, Kräkel, Matthias
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Retractable Contracts [PDF]

Electronic Proceedings in Theoretical Computer Science, 2016
In Proceedings PLACES 2015, arXiv:1602 ...
Barbanera Franco, Dezani-Ciancaglini Mariangiola, Lanese Ivan, De'Liguoro Ugo   +3 more
openaire   +5 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Tourism law: from traveller to consumer

Revista CIDOB d'Afers Internacionals, 2016
The law on tourism – “tourism law” for some authors – is the instrument that has been used to turn the tourist into a consumer. Travellers are increasingly aware of the rights they can exercise.
Oscar Casanovas Ibáñez
doaj   +1 more source