Results 31 to 40 of about 154,662 (285)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Banking risk 56: Moral hazard risk [PDF]

Bankarstvo, 2017
The exposure to moral hazard risk in business is present both in the economy and in the financial sector, and is manifested as a readiness of the contractual party to take unusual risks or not to enter contracts in good faith.
Matić Vesna
doaj  

Co-opetition and the Stability of Competitive Contractual Strategic Alliance: Thinking Based on the Modified Lotka-Voterra Model

International Journal of u- and e-Service, Science and Technology, 2015
Co-opetition is the key feature of competitive contractual strategic alliances. Original competition, inter-alliance competition and cooperation constitute all together co-opetition relations in competitive contractual strategic alliance. Such relations dictate the stability of the alliance by means of affecting the profits of alliance partners.
Xuemei Qing, Weiguo Zhang
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Matching ecological transition and food security in the cereal sector: The role of farmers' preferences on production contracts

Frontiers in Sustainable Food Systems, 2023
IntroductionUnder an increasing demand from citizen and public institutions, agri-food supply chains are requested to comply with stringent environmental requirements. Moreover, new sources of uncertainty related to pandemic and geo-political turbulences
Stefano Ciliberti, Angelo Frascarelli, Gaetano Martino   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Value Foundations of the European Integration and their Exercises in the Current Relations between Russia and the European Union

Вестник Кемеровского государственного университета, 2022
The article describes the value category behind the political development and practice of the European Union and the European integration project. Values are tools of developing the supranational ideology, identity, and political development vector.
E. R. Khayrullin
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Factors influencing farmers turning into tobacco cultivation in the Khulna division of Bangladesh: an empirical study

Tobacco Prevention and Cessation, 2019
Introduction Farmers of Khulna division of Bangladesh cultivate both tobacco and traditional crops in winter season. Some tobacco companies (TCs) operate there and make formal contracts with farmers.
Khan Mehedi Hasan
doaj   +1 more source