Results 31 to 40 of about 58,995 (250)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus [PDF]

, 2010
BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality.
Bell Christopher G, Savage, DA, Savage, David A., Savage, D.A., Bell, CG, Beck, Stephan, Stephan Beck, Maxwell, Alexander P.; id_orcid, Maxwell, Alexander P., Maxwell, A.P., Teschendorff, AE, Beck Stephan, Rakyan, VK, Rakyan, V.K., David A Savage, Teschendorff, Andrew E., Christopher G Bell, Andrew E Teschendorff, Maxwell Alexander P, Alexander P Maxwell, Bell, Christopher G., Rakyan, Vardhman K., Savage David A, Beck, S, Rakyan Vardhman K, Bell, C.G., Beck, S., Maxwell, AP, Teschendorff, A.E., Vardhman K Rakyan, Teschendorff Andrew E   +30 more
core   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Sodium bicarbonate-based hydration prevents contrast-induced nephropathy: a meta-analysis

BMC Medicine, 2009
Background Contrast-induced nephropathy is the leading cause of in-hospital acute renal failure. This side effect of contrast agents leads to increased morbidity, mortality, and health costs.
Tamhane Umesh, Tamura Akira, Ko Dennis T, Meier Pascal, Gurm Hitinder S   +4 more
doaj   +1 more source

CXCL16 and oxLDL are induced in the onset of diabetic nephropathy

, 2009
Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Amann, Kerstin Ute, El Sayed, El Sayed M., Doberstein, Kai, Kämpfer-Kolb, Nicole, Abdel-Aziz, Abdel-Aziz H., Schäfer, Liliana, Gutwein, Paul, Pfeilschifter, Josef, Abdel-Bakky, Mohamed Sadek, Beckmann, Janet, Doller, Anke, Schramme, Anja   +11 more
core   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers

British Journal of Clinical Pharmacology, EarlyView.
Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics (CPT) exams, comparing their results to medical students and exploring their ability to identify poorly formulated
Alexandre O. Gérard, Diane Merino, Marc Labriffe, Fanny Rocher, Delphine Viard, Laurence Zemori, Thibaud Lavrut, Erik M. Donker, Joost D. Piët, Jean‐Paul Fournier, Milou‐Daniel Drici, Alexandre Destere   +11 more
wiley   +1 more source

Impact of high dose versus low dose atorvastatin on contrast induced nephropathy in diabetic patients with acute coronary syndrome undergoing early percutaneous coronary intervention

The Egyptian Heart Journal, 2015
Background: Statins with its anti-inflammatory and pleiotropic effects may prevent contrast induced nephropathy in high risk diabetic patients. Aim of work: To compare between the effects of high and low dose atorvastatin on preventing contrast induced ...
Haitham Galal, Wael Nammas, Ayman Samir
doaj   +1 more source

The Incidence of Contrast-Induced Nephropathy and the Need of Dialysis in Patients Receiving Angiography: A Systematic Review and Meta-Analysis

Frontiers in Medicine, 2022
ObjectivesThe risk of dialysis following contrast exposure is unclear. We aimed to examine the overall risk of contrast induced nephropathy and the need of dialysis based on a systematic review with random-effects meta-analysis.MethodsWe searched the ...
Mei-Yi Wu, Mei-Yi Wu, Mei-Yi Wu, Mei-Yi Wu, Wei-Cheng Lo, Wei-Cheng Lo, Yun-Chun Wu, Tsu-Chen Lin, Tsu-Chen Lin, Chun-Hung Lin, Mai-Szu Wu, Mai-Szu Wu, Mai-Szu Wu, Yu-Kang Tu, Yu-Kang Tu   +14 more
doaj   +1 more source