Results 41 to 50 of about 362,940 (245)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

Diagnostics, 2016
The aim of this study was to provide an overview of the literature available on dynamic contrast-enhanced computed tomography (DCE-CT) as a tool to evaluate treatment response in patients with lung cancer. This systematic review was compiled according to
Louise S. Strauch, Rie Ø. Eriksen, Michael Sandgaard, Thomas S. Kristensen, Michael B. Nielsen, Carsten A. Lauridsen   +5 more
doaj   +1 more source

Quantitative contrast enhanced dual energy CT to predict avascular necrosis: a feasibility study of proximal humerus fractures [PDF]

, 2021
Kevin B. Hoover, Alexandria Starks, Valentina Robila, Daniel L. Riddle   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Spatial and temporal evaluation of iodine uptake and radiodensity in meniscus tissue using contrast-enhanced micro-CT

Heliyon
Rationale and objective: The visualization of soft tissues, like the meniscus, through X-ray micro-computed tomography (micro-CT), requires the use of contrast agents (CAs).
Federica Orellana, Alberto Grassi, Katja M. Nuss, Peter Wahl, Antonia Neels, Stefano Zaffagnini, Annapaola Parrilli   +6 more
doaj   +1 more source

Radiomics nomogram for preoperative differentiation of pulmonary mucinous adenocarcinoma from tuberculoma in solitary pulmonary solid nodules

BMC Cancer, 2023
Objective To develop and validate predictive models using clinical parameters, radiomic features and a combination of both for preoperative differentiation of pulmonary nodular mucinous adenocarcinoma (PNMA) from pulmonary tuberculoma (PTB).
Junjie Zhang, Ligang Hao, MingWei Qi, Qian Xu, Ning Zhang, Hui Feng, Gaofeng Shi   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Different routes of N-acetylcysteineon administration in preventing contrast-induced nephropathy in mild renal impairment patients undergoing contrast-enhanced CT

Linchuang shenzangbing zazhi, 2015
Objective To explore the preventive effect of oral and intravenous administration of N-acetylcysteine(NAC) on contrast-induced nephropathy(CIN) in patients with mild renal impairment undergoing contrast-enhanced CT.Methods A total of 97 patients with ...
XU Xiao, HUANG Min, DU Li-guo, LI Xiao-ning   +3 more
doaj  

Comparative analysis of dynamic contrast-enhanced MRI, dynamic contrast-enhanced CT, and their combination for adrenal tumor diagnosis in men [PDF]

Journal of Men's Health
This study aimed to compare the diagnostic efficacy of dynamic contrast-enhanced computed tomography (CT), dynamic contrast-enhanced Magnetic Resonance Imaging (MRI) and their combination in diagnosing adrenal tumors.
Minghui Yan, Yanan Wang, Lianghong Jiao
doaj   +1 more source

Bezold's abscess with intracranial complications of mastoiditis in an immunocompetent adult: A rare case

Otolaryngology Case Reports, 2020
Bezold's abscess is a very rare complication of mastoiditis, where the infection erodes through mastoid cortex and causes deep neck abscess. Bezold's abscess with concomitant intracranial complications of mastoiditis is even rarer.We reported a 19-year ...
Benedicta Mutiara Suwita, Indrati Suroyo, Reyhan Eddy Yunus   +2 more
doaj   +1 more source