Results 151 to 160 of about 15,851,959 (333)

La plasmació de la ironia en l’assaig periodístic de Joan F. Mira

open access: yesCultura, Lenguaje y Representación, 2018
La ironia és un fenomen enunciatiu d’ampli abast que supera amb escreix una limitada adscripció a certes figures retòriques com ara l’antífrasi. Aquest treball examina com J. F.
Sergi Serra Adsuara
doaj  

An Analysis of Visibility Requirements and Reaction Times of Near-Field Projections

open access: yesApplied Sciences
Successful communication between highly automated vehicles and vulnerable road users will be crucial in the future. In addition to the technical requirements of the communication system, the projected content is also essential to ensure successful ...
Tabea Schlürscheid   +3 more
doaj   +1 more source

The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.

open access: yesNew England Journal of Medicine, 2000
R. Kim   +8 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Increase in Non-Contrast Computerized Tomography Scans of the Head Following Popular Media Stories About Head Injury

open access: yesWestern Journal of Emergency Medicine, 2012
Introduction: On March 18, 2009, actress Natasha Richardson died after a head injury. It is possiblethat the rate of patients presenting with mild head injury and receiving computed tomographies (CTs)may have been influenced by the Richardson event.
Matthew J. Pirotte   +3 more
doaj  

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