Results 121 to 130 of about 4,621,962 (301)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Global ChallengesGadolinium‐based contrast agents (GBCAs) have revolutionized medical imaging, enhancing the accuracy and diagnostic value of magnetic resonance imaging (MRI).
Angelo Scarciglia +5 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Progress in studying iron-based magnetic resonance contrast agents
上海师范大学学报. 自然科学版In recent years, iron-based magnetic resonance contrast agents have received widespread attention in the medical imaging field due to their excellent magnetic properties and good biocompatibility.
GUO Zepei, YANG Shiping
doaj +1 more source
Preclinical Applications of Targeted Protein-Based Contrast Agents for Molecular MRI Imaging [PDF]
Magnetic resonance imaging (MRI) is a powerful technique for disease diagnosis, but extending this technology to applications in molecular imaging has been challenging due to lack of safe and effective contrast agents with required sensitivity and ...
Gui, Zongxiang
core +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
, 1994 Gadolinium(III) complexes of aminophosphonates, including a novel ligand L4H8, have been investigated as potential contrast agents for NMR imaging. Water 1H relaxivities at 10 and 200 MHz were determined and luminescence measurements, on TbIII complexes,
Sadler, P.J. +3 more
core +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Phase contrast imaging with a laboratory-based microfocus X-ray source [PDF]
, 2007 This project looks at the design of an in-line X-ray phase contrast imaging system, based around the Bede Microsource®, on a suitable scale for imaging small pathological samples. The system is applied to two test objects to assess feasibility of its use
Kelly, Kathryn L, Kelly, Kathryn L.
core