Results 231 to 240 of about 5,193,269 (304)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Assessment of Omission of Non-Contrast CT for CT Diagnosis of Abdominal Diseases in Patients Undergoing Non-Emergent Contrast-Enhanced CT Abdomen

Journal of Gastrointestinal and Abdominal Radiology
Vinita Rathi, Chandan Kumar Pal, Ashish Kumar Raj, Shuchi Bhatt   +3 more
doaj   +1 more source

A deep learning ensemble framework for multi-subtype renal tumor classification using contrast-enhanced CT. [PDF]

Sci Rep
Abdeltawab H, Alksas A, Ghazal M, Khalil A, Alghamdi NS, Abouelkheir RT, Elmahdy A, El-Ghar MA, Contractor S, El-Baz A.   +9 more
europepmc   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Correction: Severe pulmonary trunk stenosis associated with R2A-type coronary artery anomaly in a dog: echocardiographic findings and postmortem contrast-enhanced CT confirmation. [PDF]

BMC Vet Res
Szaluś-Jordanow O, Godlewska A, Mądry W, Buczyński M, Moroz-Fik A, Kwiatkowska M, Tarka S, Barszcz K.   +7 more
europepmc   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Radiomics based on multiphasic contrast-enhanced CT combined with clinical features for differentiating hypovascular pancreatic neuroendocrine tumors and pancreatic ductal adenocarcinoma. [PDF]

J Cancer Res Clin Oncol
Xia F, Yu J, Wang J, Wang Z.
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Standardized contrast-enhanced CT-based radiomics for non-invasive prediction of TTF-1 status in lung adenocarcinoma: A cross-validated single-center study. [PDF]

Eur J Radiol Open
Nüssel M, Trinks JN, Förster S, Krugmann J, Klink T.   +4 more
europepmc   +1 more source

Quantitative assessment of multi-phase contrast-enhanced CT features in hepatic epithelioid hemangioendothelioma. [PDF]

J Gastrointest Oncol
Chen H, Zhou W, Lin J, Xu Y, Li S.
europepmc   +1 more source