Results 51 to 60 of about 5,193,269 (304)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Spatial and temporal evaluation of iodine uptake and radiodensity in meniscus tissue using contrast-enhanced micro-CT

Heliyon
Rationale and objective: The visualization of soft tissues, like the meniscus, through X-ray micro-computed tomography (micro-CT), requires the use of contrast agents (CAs).
Federica Orellana, Alberto Grassi, Katja M. Nuss, Peter Wahl, Antonia Neels, Stefano Zaffagnini, Annapaola Parrilli   +6 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Different routes of N-acetylcysteineon administration in preventing contrast-induced nephropathy in mild renal impairment patients undergoing contrast-enhanced CT

Linchuang shenzangbing zazhi, 2015
Objective To explore the preventive effect of oral and intravenous administration of N-acetylcysteine(NAC) on contrast-induced nephropathy(CIN) in patients with mild renal impairment undergoing contrast-enhanced CT.Methods A total of 97 patients with ...
XU Xiao, HUANG Min, DU Li-guo, LI Xiao-ning   +3 more
doaj  

Automated Aortic Quantification Based on Artificial Intelligence: Validation Using Contrast-Enhanced and Non-Contrast CT Scans from the Same Session

Bioengineering
Early detection of aortic dilatation is clinically important for preventing progression to serious aortic disease and enabling timely intervention. We aimed to develop an AI method for quantifying the aorta in both contrast-enhanced and non-contrast CT ...
Jia-Sheng Hong, Yun-Hsuan Tzeng, Kuan-Ting Wu, Shih-Yu Huang, Ting-Wei Wang, Guan-Yu Li, Chun-Yi Lin, Ho-Ren Liu, Hai-Neng Fu, Yung-Tsai Lee, Wei-Hsian Yin, Yu-Te Wu   +11 more
doaj   +1 more source

Multimodality CT imaging contributes to improving the diagnostic accuracy of solitary pulmonary nodules: a multi-institutional and prospective study

Radiology and Oncology, 2023
Solitary pulmonary nodules (SPNs) are one of the most common chest computed tomography (CT) abnormalities clinically. We aimed to investigate the value of non-contrast enhanced CT (NECT), contrast enhanced CT (CECT), CT perfusion imaging (CTPI), and dual-
Yan Gaowu, Li Hongwei, Fan Xiaoping, Deng Jiantao, Yan Jing, Qiao Fei, Yan Gaowen, Liu Tao, Chen Jiankang, Wang Lei, Yang Yang, Li Yong, Zhao Linwei, Bhetuwal Anup, McClure Morgan A., Li Na, Peng Chen   +16 more
doaj   +1 more source

Importance of extracolonic findings at IV contrast medium-enhanced CT colonography versus those at non-enhanced CT colonography [PDF]

, 2018
To compare the clinical importance of extracolonic findings at intravenous (IV) contrast-enhanced CT colonography versus those at non-enhanced CT colonography.
Spreng, Adrian, Vock, Peter, Netzer, Peter, Dinkel, Hans-Peter, Mattich, Joerg, Hoppe, Hanno   +5 more
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Evaluation of 18F-FDG uptake in lung parenchyma compensating for tissue fraction : Comparison between non-enhanced low dose CT and intravenous contrast-enhanced diagnostic CT

, 2020
AIM: To determine how the presence of intravenous (IV) contrast-enhanced CT influences SUV measurements corrected for both attenuation and tissue fraction.
Minarik, David, Garpered, Sabine, Wollmer, Per, Frantz, Sophia, Valind, Sven, Minarik, David,, Wollmer, Per,, Garpered, Sabine,, Frantz, Sophia,, Lund University., Valind, Sven,   +10 more
core   +2 more sources

Diagnostic value of 18F-FDG PET/MRI for staging in patients with endometrial cancer

Cancer Imaging, 2020
Background Preoperative accurate assessment of endometrial cancer can assist in the planning of additional surgical options, and in predicting the prognosis.
Hideaki Tsuyoshi, Tetsuya Tsujikawa, Shizuka Yamada, Hidehiko Okazawa, Yoshio Yoshida   +4 more
doaj   +1 more source