Results 61 to 70 of about 5,006,170 (184)

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Spindle Cell Lesions of the Breast: A 12‐Year Experience

ANZ Journal of Surgery, EarlyView.
This 12‐year, single‐centre study examined 30 core‐biopsy‐diagnosed breast spindle cell lesions (BrSCL), classified as atypical (ASCL, n = 10) or bland (BSCL, n = 20). Following excision, 80% of ASCLs proved malignant, comprising sarcoma, malignant phyllodes tumour and metaplastic carcinoma.
Shalvin Jassal, Wesley Tjang, Shaun Monagle, Michael Law, Justin James   +4 more
wiley   +1 more source

Differentiating Breast Tumors from Background Parenchymal Enhancement at Contrast-Enhanced Mammography: The Role of Radiomics—A Pilot Reader Study

Diagnostics, 2021
Background: The purpose of this study was to assess the effectiveness of the radiomic analysis of contrast-enhanced spectral mammography (CESM) in discriminating between breast cancers and background parenchymal enhancement (BPE).
Ioana Boca (Bene), Anca Ileana Ciurea, Cristiana Augusta Ciortea, Paul Andrei Ștefan, Lorena Alexandra Lisencu, Sorin Marian Dudea   +5 more
doaj   +1 more source

Identification of a Circular RNA as a Potential Diagnostic and Prognostic Biomarker in Breast Cancer Through Integrated Bioinformatic and Experimental Analyses

Analytical Science Advances, Volume 7, Issue 2, December 2026.
Forty circular RNAs were found to be significantly dysregulated in microarray datasets. Expression levels of hsa_circ_0000231 were significantly upregulated in breast cancer (BC) tissues, while hsa_circ_0011385 exhibited no significant difference in expression levels. This study also revealed that hsa_circ_0000231/hsa‐miR‐5683/CCNB1 regulatory axis may
MohamadReza Hashemi, Pejman Morovat, Azin Khoshghiafeh, Novin Nikbakhsh, Mohamadreza Ahmadifard   +4 more
wiley   +1 more source

The Evolution of Breast Cancer Detection: A Review of Imaging, Machine Learning, and Multimodal Strategies

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Breast cancer is still a serious problem in the world arena, where its early and prompt detection is the most important factor in improving patient prognosis and survival. The use of traditional diagnostic techniques, such as imaging (e.g., mammography and ultrasound) and subsequent histopathological examination, is the mainstay, which ...
Likhon Chandra Sarkar, Farida Siddiqi Prity, Farhad Hussain, Anup Talukder, Mirza Raquib, Sharmina Rahman, MD Jiabul Hoque   +6 more
wiley   +1 more source

The added role of contrast-enhanced spectral mammography in the evaluation of pathological nipple discharge

The Egyptian Journal of Radiology and Nuclear Medicine, 2022
Background Nipple discharge is one of the commonest encountered complaints in the field of breast imaging. Excluding malignancy as a cause of pathological nipple discharge is of utmost importance.
Sherihan Fakhry, Rasha Wessam Abdel Rahman, Hanan Shawky Shaalan, Maher Hassan Ibraheem Hassan, Safy Hosny Tealab, Safia Badr Sayed   +5 more
doaj   +1 more source

Quantitative Assessment of Contrast Enhancement on Contrast Enhancement Spectral Mammography (CESM) and Comparison With Qualitative Assessment

Anticancer Research, 2020
Contrast enhanced spectral mammography (CESM) is a novel method of breast cancer diagnosis. Benign lesions are enhanced after contrast injection on both CESM and breast magnetic resonance imaging (MRI). Kinetic curves on breast MRI facilitate differentiation between benign and malignant lesions, while on CESM there is no such possibility and we need to
Rudnicki, Wojciech, Heinze, Sylwia, Popiela, Tadeusz, Kojs, Zbigniew, Luczynska, Elzbieta   +4 more
openaire   +4 more sources

Big Data in Cancer Genomics: Computational Foundations and Emerging Pathways for Precision Oncology

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT This review aims to explore the computational foundations of big data in cancer genomics and examine emerging pathways that support precision oncology and personalized cancer care. A narrative review approach was adopted to synthesize evidence from PubMed, Scopus, Web of Science, and IEEE Xplore.
Nur Vanu, Nur Mohammad, Fahad Ahmed, Towsif Alam, Koushik Saha, Durga Shahi, Adib Hossain, Mia Md. Tofayel Gonee Manik, Mst. Rina Parvin   +8 more
wiley   +1 more source

Potential Association of BRCA Mutation and Lymphocytic Lobulitis

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Lymphocytic lobulitis (LL) is a rare fibroinflammatory breast lesion historically associated with long‐standing Type 1 diabetes mellitus and autoimmune conditions. Recent evidence suggests possible links between LL and hereditary breast cancer syndromes, particularly BRCA mutations. We present the case of a BRCA1 mutation carrier who developed
Parul Garg, Sena Park, Femi E. Ayeni, Senarath Edirimanne   +3 more
wiley   +1 more source

Quantitative Breast Density in Contrast-Enhanced Mammography

, 2021
Contrast-enhanced mammography (CEM) demonstrates a potential role in personalized screening models, in particular for women at increased risk and women with dense breasts. In this study, volumetric breast density (VBD) measured in CEM images was compared
Francesca Caumo, Melissa L. Hill, Gisella Gennaro, Elisabetta Bezzon   +3 more
core   +1 more source