Results 201 to 210 of about 676,754 (296)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A Rare Case of a Middle Mediastinal Mass With Intense and Diffuse Contrast Enhancement. [PDF]

Cureus
VonTungeln CD, Perman BE, Llanos OL, Nale HE, Layfield LJ.   +4 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

DeBo: Contrast enhancement for image registration using binary differential evolution and bat optimization. [PDF]

PLoS One
Akram MA, Akram T, Javed U, Rafiq M, Naz M, He D.   +5 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Optimized exposer region-based modified adaptive histogram equalization method for contrast enhancement in CXR imaging. [PDF]

Sci Rep
Gangwar S, Devi R, Mat Isa NA.
europepmc   +1 more source

Proton relaxation enhancement associated with iodinated contrast agents in MR imaging of the CNS.

, 1992
J. R. Jinkins, Jennifer W. Robinson, Lisa Sisk, Gary D. Fullerton, Robert F. Williams   +4 more
openalex   +1 more source

Forget the Unneeded: Backdooring Large Language Models via Contrastive-enhanced Machine Unlearning

Association for Computational Linguistics 2025, Chen, Jie, Duan, Zhen, Mei, Congyao, Qian, Fulan, Yang, Shiji, Yang, Zhen, Zhang, Yanping, Zhao, Shu   +8 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Contrast Enhancement of the Olfactory Recess Using Heavily T2-Weighted 3D Fluid-Attenuated Inversion Recovery Imaging (FLAIR). [PDF]

Cureus
Matsuura K, Osawa I, Nagawa K, Kakemoto S, Inoue K, Kozawa E.   +5 more
europepmc   +1 more source