Results 171 to 180 of about 8,622,404 (371)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

An evolutionary view of the Fusarium core genome

open access: yesBMC Genomics
Fusarium, a member of the Ascomycota fungi, encompasses several pathogenic species significant to plants and animals. Some phytopathogenic species have received special attention due to their negative economic impact on the agricultural industry around ...
Daniel A. Gomez-Chavarria   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

"Monetary Policy and Economic Activity in Japan and the United States" [PDF]

open access: yes
A cornerstone of monetary policy making is that a looser monetary policy is associated with lower interest rates, higher growth of narrow monetary aggregates, higher output and higher inflation.
Etsuro Shioji, R. Anton Braun
core  

Can we contrast the epistemological hypothesis? [PDF]

open access: yesEnrahonar. Quaderns de filosofia, 1985
openaire   +1 more source

AutoSciDACT: Automated Scientific Discovery through Contrastive Embedding and Hypothesis Testing

open access: yes
Accepted at NeurIPS 2025; 32 pages, 16 ...
Bright-Thonney, Samuel   +8 more
openaire   +2 more sources

Hypoenhancing prostate cancers on dynamic contrast-enhanced MRI are associated with poor outcomes in high-risk patients: results of a hypothesis generating study

open access: green, 2018
Valdair Francisco Muglia   +5 more
openalex   +1 more source

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