Results 101 to 110 of about 21,692,993 (303)
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Binocular contrast vision at and above threshold [PDF]
, 2006 A fundamental problem for any visual system with binocular overlap is the combination of information from the two eyes. Electrophysiology shows that binocular integration of luminance contrast occurs early in visual cortex, but a specific systems ...
Georgeson, Mark A. +6 more
core +1 more source
Value of contrast-enhanced ultrasound in diagnosis of bladder occupied lesions
肿瘤影像学, 2018 Objective: To investigate the clinical application value of contrast-enhanced ultrasound (CEUS) in the diagnosis of bladder occupied lesions.
LIU Qiping +5 more
doaj
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
مجلة بغداد للعلومThe objective of the present work aims to find an alternative oral contrast agent that could be used in magnetic resonance imaging (MRI) of the gastrointestinal system and satisfy the following criteria: it should be safe, it has no or few side effects,
Zainab Abdulla Mankhi +2 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
A real time object tracking system for contrast media injection
, 2010 Contrast media is widely used in hospital for a better imaging of CT angiography. However, emergencies (such as needle eruption and capillary hemorrhage) may exist due to the extreme high speed of injection.
Wang ZL(王哲龙) +2 more
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Iodinated contrast media : risk and best practice [PDF]
, 2015 The aim of administering contrast media in medical imaging is to improve image contrast and the diagnostic efficacy of the imaging examination being undertaken. Developments in the manufacture of iodinated contrast media have led to an increase in safety
Mizzi, Adrian, Zarb, Francis
core