Results 151 to 160 of about 3,150,566 (296)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

When Premedication Fails: Anaphylaxis to Iodinated Contrast Media in the Cardiac Catheterization Lab Despite Premedication. [PDF]

JACC Case Rep
Trinh AT, McMurray JC, Pittman LM, Ryaboy IV.   +3 more
europepmc   +1 more source

Effect of radiologic contrast media and local anaesthetics on the blood-brain barrier and on the leptomeninges

, 1983
Bertil Vällfors, Hans‐Arne Hansson, Mohamed Belghmaïdi, Lars Irstam, Lennart Persson   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Retrieval-augmented generation elevates local LLM quality in radiology contrast media consultation. [PDF]

NPJ Digit Med
Wada A, Tanaka Y, Nishizawa M, Yamamoto A, Akashi T, Hagiwara A, Hayakawa Y, Kikuta J, Shimoji K, Sano K, Kamagata K, Nakanishi A, Aoki S.   +12 more
europepmc   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Myasthenia Gravis following Low-Osmolality Iodinated Contrast Media

Case Reports in Radiology, 2014
Luca Bonanni, Michele Dalla Vestra, Andrea Zancanaro, Fabio Presotto   +3 more
doaj   +1 more source

Innovation and Optimization of Contrast Media Administration in Computed Tomography. [PDF]

Korean J Radiol
Caruso D.
europepmc   +1 more source

Contrast Media Adversely Affect Oxyhemoglobin Dissociation

, 1990
Song‐Jung Kim, M. Ramez Salem, Ninos J. Joseph, Manuel A. Madayag, Robert P. Cavallino, George J. Crystal   +5 more
openalex   +1 more source