Results 151 to 160 of about 9,155,379 (405)

Postoperative MRI Findings Following PELD and Their Correlations with Clinical Prognosis are Investigated by Injecting Contrast into Annulus Fibrosus Intraoperatively

open access: yesJournal of Pain Research
Jinhui Bu,1,2,* Zhenfei Wang,2,* Chao Ma,1,2 Juan Gao,2 Guangpu Liu,2 Libo Pang,2 Bo He,1 Minghui Dong,1 Quan Zhang,1 Yan Lei,1 Long Xu,2 Sen Huang,1 Yuming Li,3 Guangwang Liu1,2 1Xuzhou Clinical School of Xuzhou Medical University, Xuzhou ...
Bu J   +13 more
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Safety and Performance of OptiVantage, a CT Contrast Media Injector, in Multi-Patient Mode

open access: yesMedical Devices: Evidence and Research
Angela Tirri,1 Filippo Nicolò Iannelli,2 Anthony Sequeira,3 Frantz Hebert3 1Studio Medico Associato Dott.ssa Tirri Angela sas, Licata, Italy; 2Centri Iannelli Diagnosi, - Barcellona Pozzo di Gotto ME, Messina, Italy; 3Clinical Development Department ...
Tirri A   +3 more
doaj  

Clinical study of different hydration ways to prevent contrast induced nephropathy

open access: yesLinchuang shenzangbing zazhi, 2015
Objective To compare different approaches of saline water supplement for the treatment and prevention of contrast induced nephropathy effects,so as to find the best water treatment method for the clinical therapeutic and improve the hydration effect of ...
XIE Yu-bo   +3 more
doaj  

Contrast medium administration and image acquisition parameters in renal CT angiography: what radiologists need to know

open access: yesDiagnostic and Interventional Radiology, 2016
Over the last decade, exponential advances in computed tomography (CT) technology have resulted in improved spatial and temporal resolution. Faster image acquisition enabled renal CT angiography to become a viable and effective noninvasive alternative in
Charbel Saade   +4 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

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